US2026000731A1PendingUtilityA1

Anti-pathogen composition and methods of use thereof

Assignee: TENFOLD TECH LLCPriority: Mar 27, 2017Filed: Jan 17, 2025Published: Jan 1, 2026

Est. expiryMar 27, 2037(~10.7 yrs left)· nominal 20-yr term from priority

Inventors:GUAN SHAOHUA RAJBANSHI SHASHI SHANKAR HILL CURTIS BRIAN QIU SHI LI XING-CONG

C12N 1/20Y02A50/30C12P 21/02A61K 38/15A61P 31/04A61K 38/164A61P 31/10

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References

Claims

Abstract

Methods are provided for treating an infectious disease of a subject with a composition which comprises an active ingredient that can be produced by bacteria of Paenibacillus or Bacillus. The disclosure also provides a composition or a pharmaceutical composition which comprises, or alternatively consists essentially of, or yet further consists of an active ingredient which can be produced by bacteria of Paenibacillus or Bacillus.

Claims

exact text as granted — not AI-modified

1 - 55 . (canceled) 
     
     
         56 . A method of preventing or treating an infection by a pathogen in an animal, the method comprising administering to the animal an effective amount of i) a  Paenibacillus  bacteria, wherein the  Paenibacillus  bacteria comprises MS1479 (ATCC Accession No. PTA-124701), MS2379 (ATCC Accession No. PTA-124703), MS2414 (ATCC Accession No. PTA-124704), or MS2820 (ATCC Accession No. PTA-124710), or ii) a  Bacillus  bacteria, wherein the  Bacillus  bacteria comprises MS0633 (ATCC Accession No. PTA-124700), MS2335 (ATCC Accession No. PTA-124702), MS2652 (ATCC Accession No. PTA-124705), MS2658 (ATCC Accession No. PTA-124706), MS2681 (ATCC Accession No. PTA-124707), MS2697 (ATCC Accession No. PTA-124708), MS2712 (ATCC Accession No. PTA-124709), or MS2341, or MS2337; and wherein the pathogen comprises an infectious microbe. 
     
     
         57 . The method of  claim 56 , wherein the animal is a non-human animal. 
     
     
         58 . The method of  claim 57 , wherein the administering comprises administering the  Paenibacillus  bacteria MS2379 (ATCC Accession No. PTA-124703), the  Paenibacillus  bacteria MS2414 (ATCC Accession No. PTA-124704), or the  Paenibacillus  bacteria MS2820 (ATCC Accession No. PTA-124710). 
     
     
         59 . The method of  claim 57 , wherein the infectious microbe comprises a bacterium. 
     
     
         60 . The method of  claim 59 , wherein the bacterium comprises a gram-positive bacterium. 
     
     
         61 . The method of  claim 60 , wherein the gram-positive bacterium comprises a  Streptococcus  sp. 
     
     
         62 . The method of  claim 57 , wherein the non-human animal is a pig. 
     
     
         63 . The method of  claim 57 , wherein the administering comprises oral administering. 
     
     
         64 . The method of  claim 60 , wherein the gram-positive bacterium comprises an  Enterococcus  sp. 
     
     
         65 . The method of  claim 57 , wherein the non-human animal is a bird. 
     
     
         66 . The method of  claim 57 , wherein the administering comprises administering the  Bacillus  bacteria MS2652 (ATCC Accession No. PTA-124705). 
     
     
         67 . The method of  claim 57 , wherein the administering comprises administering the  Bacillus  bacteria MS2341, the  Bacillus  bacteria MS2337, the  Bacillus  bacteria MS0633 (ATCC Accession No. PTA-124700), the  Bacillus  bacteria MS2335 (ATCC Accession No. PTA-124702), the  Bacillus  bacteria MS2681 (ATCC Accession No. PTA-124707), the  Bacillus  bacteria MS2697 (ATCC Accession No. PTA-124708), or the  Bacillus  bacteria MS2712 (ATCC Accession No. PTA-124709). 
     
     
         68 . The method of  claim 60 , wherein the gram-positive bacterium comprises a  Staphylococcus  sp. 
     
     
         69 . The method of  claim 68 , wherein the  Staphylococcus  sp. comprises  Staphylococcus aureus.    
     
     
         70 . The method of  claim 60 , wherein the gram-positive bacterium comprises  Streptococcus agalactiae.    
     
     
         71 . The method of  claim 59 , wherein the bacterium comprises a  Klebsiella  sp. or  Escherichia coli.    
     
     
         72 . The method of  claim 57 , wherein the non-human animal comprises cattle. 
     
     
         73 . The method of  claim 57 , wherein the administering comprises topical administering. 
     
     
         74 . A method comprising administering to an animal i) a  Paenibacillus  bacteria, wherein the  Paenibacillus  bacteria comprises MS1479 (ATCC Accession No. PTA-124701), MS2379 (ATCC Accession No. PTA-124703), MS2414 (ATCC Accession No. PTA-124704), or MS2820 (ATCC Accession No. PTA-124710), or ii) a  Bacillus  bacteria, wherein the  Bacillus  bacteria comprises MS2341, MS2337, MS0633 (ATCC Accession No. PTA-124700), MS2335 (ATCC Accession No. PTA-124702), MS2652 (ATCC Accession No. PTA-124705), MS2658 (ATCC Accession No. PTA-124706), MS2681 (ATCC Accession No. PTA-124707), MS2697 (ATCC Accession No. PTA-124708), or MS2712 (ATCC Accession No. PTA-124709). 
     
     
         75 . The method of  claim 74 , wherein the administering comprises administering the  Bacillus  bacteria MS0633 (ATCC Accession No. PTA-124700). 
     
     
         76 . The method of  claim 74 , wherein the administering comprises administering a dry formulation. 
     
     
         77 . The method of  claim 74 , wherein the animal comprises a non-human animal. 
     
     
         78 . The method of  claim 77 , wherein the non-human animal comprises cattle. 
     
     
         79 . The method of  claim 77 , wherein the non-human animal comprises a pig. 
     
     
         80 . The method of  claim 74 , wherein the administering comprises oral administering.

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