Application of toosendanin in inhibiting aurka kinase

Abstract

The present disclosure provides the application of toosendanin in inhibiting AURKA kinase, which belongs to the technical field of toosendanin application. The present disclosure can significantly reduce the expression of AURKA kinase at the protein level. Through qPCR experiments, Western Blot experiments, and Immunofluorescence experiments, the present disclosure demonstrated that toosendanin can inhibit the expression of AURKA kinase in dose-dependent manner at the protein level by contacting toosendanin with target cells.

1 . An application of toosendanin in inhibiting AURKA kinase. 
     
     
         2 . The application of toosendanin in inhibiting AURKA kinase according to  claim 1 , wherein the toosendanin inhibits an expression of AURKA kinase at a protein level. 
     
     
         3 . The application of toosendanin in inhibiting AURKA kinase according to  claim 1 , wherein the application comprises: contacting the toosendanin with target cells. 
     
     
         4 . The application of toosendanin in inhibiting AURKA kinase according to  claim 1 , wherein the toosendanin is used alone or in combination with other medicinal ingredients. 
     
     
         5 . The application of toosendanin in inhibiting AURKA kinase according to  claim 1 , wherein the toosendanin is capable of being made into tablets, capsules, electuaries, drops, granules or injections for use. 
     
     
         6 . The application of toosendanin in inhibiting AURKA kinase according to  claim 1 , wherein the application of toosendanin in inhibiting AURKA kinase further comprises using the toosendanin in a preparation of drugs for the prevention and/or treatment of tumors. 
     
     
         7 . A drug for a prevention and/or treatment of tumors, characterized by comprising an active ingredient toosendanin.