Dosing apparatus for pharmaceutical purposes and method for operating a dosing apparatus

Abstract

A dosing apparatus for pharmaceutical purposes includes a container having a wall and an interior enclosed by the wall, and a connection device for connecting the dosing apparatus to a pharmaceutical facility for processing a liquid pharmaceutical product. The connection device is integrated in the wall and includes at least one closure element for selectively closing an opening, a chassis for moving the dosing apparatus on a set-down surface, and a dosing tool in the interior. The dosing tool has a fluid conduit for guiding the product and a dosing unit for dosing and/or conveying the product through the fluid conduit. The fluid conduit is moveable out of the interior when the closure element is open. A method for operating the dosing apparatus includes the step of connecting the container to a chamber, in which a dosing tool is included.

1 . A dosing apparatus for pharmaceutical purposes, the dosing apparatus comprising:
 a container that is closed, the container having a wall and an interior enclosed by the wall;   at least one connection device for connecting the dosing apparatus to a pharmaceutical facility for processing a liquid pharmaceutical product, wherein the at least one connection device is integrated in the wall and comprises at least one closure element for selectively closing an opening;   a chassis for moving the dosing apparatus on a set-down surface; and   at least one dosing tool in the interior, which has a fluid conduit for guiding the liquid pharmaceutical product and a dosing unit for at least one of dosing and conveying the liquid pharmaceutical product through the fluid conduit, wherein the fluid conduit is moveable out of the interior when the at least one closure element is open.   
     
     
         2 . The dosing apparatus according to  claim 1 , wherein at least one of the following applies:
 the container is or forms an isolating device, with a defined atmosphere in the interior;   the container has a RABS property;   the container is liquid-tight and/or gas-tight.   
     
     
         3 . The dosing apparatus according to  claim 1 , wherein the at least one dosing tool further comprises at least one of:
 a product container for accommodating the liquid pharmaceutical product, to which the fluid conduit is connected, wherein the dosing apparatus comprises in the interior, a holding element for arranging the product container in a defined manner; and   a filter element connected into the fluid conduit, wherein the fluid conduit is connected to an outlet of the product container and the filter element is connected into the fluid conduit.   
     
     
         4 . The dosing apparatus according to  claim 3 , further comprising a further fluid conduit as a dosing tool, wherein a feedthrough device for feeding the further fluid conduit into the interior from outside is arranged in the wall and the further fluid conduit is connected to an inlet of the product container, wherein the filter element is connected into the further fluid conduit in the interior or outside the container. 
     
     
         5 . The dosing apparatus according to  claim 4 , further comprising, outside the interior, a product container for accommodating the liquid pharmaceutical product, to which the further fluid conduit or the fluid conduit is connected, wherein the dosing apparatus comprises, outside the interior, a holding element for arranging the product container in a defined manner. 
     
     
         6 . The dosing apparatus according to  claim 5 , wherein the holding element is arranged on or secured to the container. 
     
     
         7 . The dosing apparatus according to  claim 1 , wherein the dosing apparatus comprises a feedthrough device in the wall for feeding the fluid conduit into the interior from outside. 
     
     
         8 . The dosing apparatus according to  claim 7 , wherein the at least one connection device and the feedthrough device are arranged on opposite sides of the container. 
     
     
         9 . The dosing apparatus according to  claim 1 , wherein the dosing apparatus comprises, in the interior, a receptacle for detachably mounting the dosing unit. 
     
     
         10 . The dosing apparatus according to  claim 9 , wherein at least one adapter element is provided for detachably mounting different types of dosing units on the receptacle. 
     
     
         11 . The dosing apparatus according to  claim 1 , wherein a peristaltic pump, a rotary piston pump, a time-pressure dosing unit and/or a multi-dosing aggregate is provided as the dosing unit. 
     
     
         12 . The dosing apparatus according to  claim 1 , wherein the interior is divided into a first zone and a second zone by means of a separating element, wherein the first zone has a higher level of cleanliness than the second zone, wherein the separating element is or comprises a partition wall. 
     
     
         13 . The dosing apparatus according to  claim 12 , wherein:
 the at least one dosing tool further comprises a product container for accommodating the liquid pharmaceutical product, and   at least one of:
 the fluid conduit, in its entirety or in part, and a filling needle connected to the fluid conduit are arranged in the first zone, or 
 the product container is arranged in the second zone. 
   
     
     
         14 . The dosing apparatus according to  claim 1 , wherein at least one glove port for a user is provided on the container. 
     
     
         15 . The dosing apparatus according to  claim 1 , wherein the at least one dosing tool comprises at least one filling needle, which is connected to the fluid conduit and is arranged in the interior. 
     
     
         16 . The dosing apparatus according to  claim 15 , wherein at least one of the following applies:
 the dosing apparatus comprises, in the interior, a holding part for arranging the at least one filling needle in a defined manner;   the holding part is arranged on the at least one closure element, which is pivotable out of the interior when the at least one connection device is opened.   
     
     
         17 . The dosing apparatus according to  claim 16 , wherein the holding part is formed to be size-adjustable or length-adjustable and is transferable from a storage position to a use position, in which the at least one filling needle is movable so as to be at a distance from the container when the at least one closure element is open. 
     
     
         18 . The dosing apparatus according to  claim 1 , wherein the dosing apparatus comprises a further connection device integrated in the wall and having at least one further closure element. 
     
     
         19 . The dosing apparatus according to  claim 1 , wherein the dosing apparatus comprises a gassing device, which comprises, in the interior, a gas container for a gas, a gas conduit connected thereto, and an outlet element thereon, wherein the gas conduit is guidable out of the interior when the at least one closure element is open. 
     
     
         20 . The dosing apparatus according to  claim 1 , wherein:
 the dosing apparatus is decontaminatable and/or sterilizable, and/or   the dosing apparatus has, in the interior, a decontamination device and/or a sterilization device.   
     
     
         21 . The dosing apparatus according to  claim 1 , wherein the dosing apparatus comprises a climate control device for adjusting at least one of a temperature and a humidity content in the interior. 
     
     
         22 . The dosing apparatus according to  claim 1 , wherein the dosing apparatus comprises a ventilation device for providing an air flow in the interior. 
     
     
         23 . The dosing apparatus according to  claim 1 , wherein at least one of the following applies:
 the dosing apparatus is manually guided;   the chassis has a traction drive;   the dosing apparatus is configured self-driving and self-steering.   
     
     
         24 . A method for operating a dosing apparatus according to  claim 1 , the method comprising the steps of:
 connecting the container to a chamber, in which at least one dosing tool is included; and   transferring the at least one dosing tool into the interior of the container and uncoupling the dosing apparatus from the chamber.   
     
     
         25 . The method according to  claim 24 , further comprising the steps of:
 connecting the container to a facility for processing a liquid pharmaceutical product;   retrieving the fluid conduit and transferring the fluid conduit into the facility; and   operating the dosing unit to supply the liquid pharmaceutical product.