P
US3944673AExpiredUtilityPatentIndex 92

Hexahydro-dibenzo[b,d]pyran-9-ones as analgesic drugs

Assignee: LILLY CO ELIPriority: Nov 5, 1973Filed: May 23, 1975Granted: Mar 16, 1976
Est. expiryNov 5, 1993(expired)· nominal 20-yr term from priority
Inventors:ARCHER ROBERT A
C07C 49/747C07D 311/80
92
PatentIndex Score
39
Cited by
2
References
7
Claims

Abstract

Use of 1-hydroxy-3-alkyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-ones as an analgesic drug and pharmaceutical compositions containing same.

Claims

exact text as granted — not AI-modified
I claim: 
     
       1. A process for providing analgesia to mammals suffering from pain which comprises administering to a mammal in need of analgesia an analgetic dose of a compound represented by the formula ##SPC7## wherein R' is either C 7  -C 10  normal alkyl or is the group ##EQU3## wherein R" is C 2  -C 7  alkyl and R v  is H or methyl, wherein both R groups are identical and are H or methyl and wherein R'" is H or C 1  -C 4  alkanoyl, in an amount effective to provide analgesia.   
     
     
       2. A process according to claim 1 in which a dose of from 0.1 to 100 mgs per day of the drug is administered. 
     
     
       3. A process according to claim 1 in which a dose of from 1 to 20 mgs. per day of the drug is administered. 
     
     
       4. A process according to claim 1 in which the drug is administered by the oral route. 
     
     
       5. A process according to claim 1 in which dl-trans-1-hydroxy-3-(1',1'-dimethylheptyl)-6,6a,7,8,10,10a-hexahydro-6,6-dimethyl-9H-dibenzo[b,d]pyran-9-one is administered. 
     
     
       6. A process according to claim 1 in which dl-trans-1-hydroxy-3-(1',2'-dimethylheptyl)-6,6a,7,8,10,10a-hexahydro-6,6-dimethyl-9H-dibenzo[b,d]pyran-9-one is administered. 
     
     
       7. A process according to claim 1 in which dl-trans-1-hydroxy-3-(1'-methylheptyl)-6,6a,7,8,10,10a-hexahydro-6,6-dimethyl-9H-dibenzo[b,d]pyran-9-one is administered.

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