Araliphatic ketones and carbinols

Abstract

Compounds of the formula WHEREIN R1 is isobutyl, phenyl, o-fluoro-phenyl, o-chloro-phenyl, cyclopentyl, cyclohexyl, methyl-cyclo-hexyl or cycloheptyl, R2 is hydrogen, fluorine, chlorine or bromine, R3 is methyl, ethyl or, when R1 is phenyl, fluoro-phenyl or chloro-phenyl, or R1 is cyclohexyl and R2 is halogen, also hydrogen, Z1 and Z2 are hydrogen or together form an additional carbon-to-carbon bond, A is O PARALLEL -C- or HOH ANGLE -C- and M IS 2, 4, 6, 8 OR WHEN R1 is halo-phenyl, isobutyl, cyclohexyl, methyl-cyclohexyl, cyclopentyl or cycloheptyl and/or R2 is halogen and/or R3 is methyl or ethyl and/or A is -CH(OH)-, also O; the compounds are useful as antiphlogistics.

We claim: 
     
       1. A compound of the formula ##SPC24## wherein   R 1  is phenyl, o-fluoro-phenyl or o-chloro-phenyl,   R 2  is hydrogen, fluorine, chlorine or bromine,   R 3  is hydrogen, methyl, or ethyl,   Z 1  and Z 2  are each hydrogen or together form an additional carbon-to-carbon bond, and   m is 2,4,6,8 or, when R 1  is halo-phenyl and/or R 2  is halogen and/or R 3  is methyl or ethyl, also O.   
     
     
       2. The compound of claim 1 which is 6-(2-fluoro-4-biphenylyl)-2-hexanone. 
     
     
       3. The compound of claim 1 which is 4-(4-biphenylyl)-2-pentanone. 
     
     
       4. The compound of claim 1 which is 8-(2'-fluoro-4-biphenylyl)-2-octanone. 
     
     
       5. The compound of claim 1 which is (E)-4-(4-biphenylyl)-3-pentene-2-one. 
     
     
       6. The compound of claim 1 which is (E)-4-(2'-fluoro-4-biphenylyl)-2-pentene-2-one. 
     
     
       7. The compound of claim 1 which is (E) -4-(2'-fluoro-4-biphenylyl)-3-pentene-2-one.