2,4,6-Triiodo-5-methoxyacetamido-N-methylisophthalamic acid and salts, acyl halides and esters thereof

Abstract

2,4,6-Triiodo-5-methoxyacetamido-N-methylisophthalamic acid and salts and esters thereof are useful as x-ray contrast agents. The corresponding acyl halides are useful as intermediates.

What is claimed is: 
     
       1. A compound selected from the group consisting of 2,4,6-triiodo-5-methoxyacetamido-N-methylisophthalamic acid, the ammonium salt thereof, salts thereof with pharmaceutically acceptable cations, lower alkyl esters thereof, and the acyl halide thereof. 
     
     
       2. A compound as defined by claim 1 which is 2,4,6-triiodo-5-methoxyacetamido-N-methylisophthalamic acid. 
     
     
       3. A compound as defined by claim 1 which is a salt of 2,4,6-triiodo-5-methoxyacetamido-N-methylisophthalamic acid with a pharmaceutically acceptable cation. 
     
     
       4. A compound as defined by claim 3 wherein the pharmaceutically acceptable cation is sodium. 
     
     
       5. A compound as defined by claim 3 wherein the pharmaceutically acceptable cation is meglumine. 
     
     
       6. A compound as defined by claim 1 which is 2,4,6-triiodo-5-methoxyacetamido-N-methylisophthalamoyl chloride. 
     
     
       7. A compound as defined by claim 1 which is ethyl 2,4,6-triiodo-5-methoxyacetamido-N-methylisophthalamate.