1,2,4-benzothiadiazines

Abstract

Novel 1,2,4-benzothiadiazines substituted with an amino, alkylamino, or dialkylamino group in the 3-position are useful as central nervous system depressants and as diuretics.

What is claimed is: 
     
       1. A compound having the structure ##SPC23## wherein R 1  is amino, alkylamino, or dialkylamino; R 2  is phenyl or phenyl substituted with halogen, nitro, trifluoromethyl, alkyl or alkoxy; R 3  is hydrogen, halogen, nitro, cyano, trifluoromethyl, alkyl, or alkoxy; R 4  is hydrogen or ##EQU4## and R 5  is hydrogen or alkyl; or a pharmaceutically acceptable acid-addition salt thereof; wherein the terms alkyl and alkoxy refer to groups having 1 to 8 carbon atoms. 
     
     
       2. A compound in accordance with claim 1 having the structure ##SPC24## 
     
     
       3. A compound in accordance with claim 1 having the structure ##SPC25## 
     
     
       4. A compound in accordance with claim 1 wherein R 1  is amino. 
     
     
       5. A compound in accordance with claim 1 wherein R 1  is alkylamino. 
     
     
       6. A compound in accordance with claim 1 wherein R 1  is dialkylamino. 
     
     
       7. A compound in accordance with claim 1 wherein R 2  is phenyl. 
     
     
       8. A compound in acccordance with claim 1 wherein R 3  is halogen. 
     
     
       9. A compound in accordance withe claim 8 wherein R 3  is chloro. 
     
     
       10. The compound in accordance with claim 1 having the name 7-chloro-3-methylamino-1-phenyl-1,2,4-benzothiadiazine-1-oxide, hydrochloride (1:1), hydrate (1:1).