1,2,3,4,6,7,8,8A-Octahydro-6-aryl-isoquinolines and derivatives thereof

Abstract

1,2,3,4,6,7,8,8a-Octahydro-6-phenyl or substituted phenyl-isoquinolines and derivatives thereof and their methods of preparation are disclosed. These compounds are useful as anti-inflammatory agents.

What is claimed is: 
     
       1. A compound of the formula ##SPC6## wherein Z is phenyl or methoxyphenyl; R 1  is methyl or benzyl; and a pharmaceutically acceptable salt thereof.   
     
     
       2. The compound of claim 1 having the name 1,2,3,4,6,7,8,8a-octahydro-2-methyl-6-phenyl-7,8-isoquinolinedicarboxylic acid anhydride, hydrochloride, 
     
     
       3. A compound of the formula: ##SPC7## wherein Z is phenyl or methoxyphenyl; R 1  is methyl or benzyl; and a   
     
     
       4. The compound having the name 2-benzyl-1,2,3,4,6,7,8,8a-octahydro-6-(p-methoxyphenyl)-7,8-isoquinoline-d 
     
     
       5. The compound of claim 3 having the name 1,2,3,4,6,7,8,8a-octahydro-6-(p-methoxyphenyl)-2-methyl-7,8-isoquinoline-d 
     
     
       6. The compound having the name 1,2,3,4,6,7,8,8a-octahydro-2-methyl-6-phenyl-7,8-isoquinolinedicarboxylic 
     
     
       7. The method of preparing the compound of claim 1 which comprises the step of reacting the hydrochloride salt of a compound of the formula ##SPC8## wherein z and R 1  are as defined in claim 1 with maleic anhydride in a lower alkanoic acid - lower alkanoic acid anhydride mixture at a temperature of from about 75° to about 175°C.