Bis-imidazolyl-bisphenylmethane and salts thereof

Abstract

Bis-imidazolyl-bisphenylmethane derivatives and pharmaceutically acceptable non-toxic salts thereof are useful as antimycotics especially against dermatomycosis caused by Trichophyton and Microsporium species and also against yeast infections of the skin and internal organs.

What is claimed is: 
     
       1. A compound of the formula: ##SPC4## wherein   R 1  is hydrogen, alkyl of 1 to 4 carbon atoms or phenyl,   R 2  and R 3  are the same or different and are hydrogen, alkyl of 1 to 4 carbon atoms or phenyl,   X and Y are the same or different and are halogen, NO 2 , CN, alkyl of 1 to 12 carbon atoms, S-alkyl of 1 to 4 carbon atoms or alkoxy of 1 to 4 carbon atoms, and   m is 0, 1 or 2, and   n is 1 or 2 or m is 1 or 2 and n is 0, 1 or 2.   
     
     
       2. A compound according to claim 1 wherein R 1  is hydrogen or alkyl of 1 to 4 carbon atoms, R 2  and R 3  are hydrogen, X and Y are the same or different and are halogen, CN, NO 2 , methoxy or methyl and n is 0 or 1. 
     
     
       3. A compound of the formula ##SPC5## wherein R 1 , R 2  and R 3  are hydrogen, X and Y are the same or different and are fluorine, chlorine, bromine, iodine, CN, NO 2 , methoxy, or thiomethyl and m and n are 1.   
     
     
       4. A compound of the formula ##SPC6## wherein R 1 , R 2  and R 3  are hydrogen, and one of X and Y is halogen in the 2-, 3- or 4-position.   
     
     
       5. The compound bis-imidazolyl-4-chlorophenyl-phenylmethane. 
     
     
       6. The compound bis-imidazolyl-4-fluorophenyl-phenylmethane. 
     
     
       7. The compound bis-imidazolyl-2,4'-difluoro-diphenylmethane. 
     
     
       8. The compound bis-imidazolyl-2-chlorophenyl-phenylmethane. 
     
     
       9. The compound bis-imidazolyl-3-chlorophenyl-phenylmethane. 
     
     
       10. The compound bis-imidazolyl-4-cyanophenyl-phenylmethane. 
     
     
       11. The compound bis-(2-methylimidazolyl)-4-chlorophenyl-phenylmethane.