Analgesic formulations having enhanced therapeutic activity

Abstract

This application describes analgesic formulations including d 2-(6-methoxy-2-naphthyl)propionic acid, or a pharmaceutically acceptable salt or ester thereof, in combination with at least one central nervous system active analgesic compound. Analgesic activity of the combination is greater than that obtained with either of the components alone, thus demonstrating enhanced analgesia which can be obtained therewith.

What is claimed is: 
     
       1. An analgesic formulation comprising, as a first component, about 50 to about 750 mg. of d 2-(6-methoxy-2-naphthyl)propionic acid, or a pharmaceutically acceptable salt thereof, and, in combination therewith, as a second component, codeine or a pharmaceutically acceptable salt thereof; said components being present in the ratio of 0.16 part to about 0.32 part by weight of said second component, expressed as codeine sulfate, per part by weight of said first component, expressed as d 2-(6-methoxy-2-naphthyl)propionic acid; said formulation exhibiting enhanced analgesic activity over that which can be obtained utilizing either of said components alone. 
     
     
       2. The formulation of claim 1 wherein said first component comprises d 2-(6-methoxy-2-naphthyl)propionic acid. 
     
     
       3. The formulation of claim 1 wherein said first component comprises the sodium salt of d 2-(6-methoxy-2-naphthyl)propionic acid. 
     
     
       4. The formulation of claim 1 wherein said second component comprises codeine. 
     
     
       5. The formulation of claim 1 wherein said second component comprises codeine sulfate. 
     
     
       6. The formulation of claim 1 comprising about 275 mg. of the sodium salt of d 2-(6-methoxy-2-naphthyl)propionic acid and about 60 mg. of codeine sulfate. 
     
     
       7. The formulation of claim 1 comprising about 550 mg. of the sodium salt of d 2-(6-methoxy-2-naphthyl)propionic acid and about 60 mg. of codeine sulfate. 
     
     
       8. The formulation of claim 1 further including a nontoxic pharmaceutically acceptable carrier in combination therewith. 
     
     
       9. A method of treating a mammal to relieve pain which comprises administering to said mammal therapeutically effective amount of an analgesic formulation comprising, as a first component, about 50 to about 750 mg. of d 2-(6-methoxy-2-naphthyl)propionic acid, or a pharmaceutically acceptable salt thereof, and, in combination therewith, as a second component, codeine, or a pharmaceutically acceptable salt thereof; said components being present in the ratio of 0.16 to about 0.32 part by weight of said second component, expressed as codeine sulfate, per part by weight of said first component, expressed as d 2-(6-methoxy-2-naphthyl)-propionic acid; said formulation exhibiting enhanced analgesic activity over that which can be obtained utilizing either of said components alone. 
     
     
       10. The method of claim 9 wherein said first component comprises d 2-(6-methoxy-2-naphthyl)propionic acid. 
     
     
       11. The method of claim 9 wherein said first component comprises the sodium salt of d 2-(6-methoxy-2-naphthyl)propionic acid. 
     
     
       12. The method of claim 9 wherein said second component comprises codeine. 
     
     
       13. The method of claim 9 wherein said second component comprises codeine sulfate. 
     
     
       14. The method of claim 9 wherein said formulation comprises about 275 mg. of the sodium salt of d 2-(6-methoxy-2-naphthyl)propionic acid and about 60 mg. of codeine sulfate. 
     
     
       15. The method of claim 9 wherein said formulation comprises about 550 mg. of the sodium salt of d 2-(6-methoxy-2-naphthyl)propionic acid and about 60 mg. of codeine sulfate.