6-[(2-Oxo-1-pyridinyl)acylamino]penicillin derivatives

Abstract

Novel [substituted(2-oxo-1-pyridinyl)acetylamino] penicillin and cephalosporin derivatives are prepared which are useful antibacterial agents.

What is claimed is: 
     
       1. A 6[(2-oxo-1-pyridinyl)amino]penicillin derivative having the formula: ##SPC15##in which either R 1  or R 2  is selected from the group consisting of hydrogen, halogen, hydroxyl, lower alkyl, tri-fluoromethyl, nitro, amino, cyano, carboxy, carbomethoxy and carbethoxy; R 3  is selected from the group consisting of hydrogen, halogen, hydroxyl, lower alkyl, trifluoromethyl, nitro, amino, cyano, carboxy, carbomethoxy, carbethoxy, and which when taken in combination with R 2  forms the cyclic radical -CH 2  CH 2  CH 2  - and -CH=CH-CH=CH-;   R 4  is selected from the group consisting of hydrogen, methyl, carboxy, carbomethoxy and carbethoxy; and the pharmaceutically acceptable salts thereof.   
     
     
       2. The compound of claim 1 which is 6-[2-(2-oxo-1-pyridyl)acetylamino]penicillanic acid and the pharmaceutically acceptable salts thereof. 
     
     
       3. A compound of claim 1 which is 6-[2-(5-chloro-2-oxo-1-pyridyl)acetylamino]penicillanic acid and the pharmaceutically acceptable salts thereof. 
     
     
       4. A compound according to claim 1 wherein R 4  is hydrogen.