Hypolipidemic bis(pivaloylbenzyl) ureas

Abstract

Pivaloyl benzyl ureas, e.g., 1,1-bis(4-pivaloylbenzyl)-3-methyl urea, are prepared by reacting a corresponding 4", 4'"-iminodimethylene-di-tert. alkylophenones with an alkyl isocyanate, and are useful as hypolipidemic agents.

What is claimed is: 
     
       1. A compound of the formula ##STR6## where R 1  represents lower alkyl having 1 to 4 carbon atoms, and R 2  each independently represents hydrogen, halo having an atomic weight of about 19 to 36, and   R 3  and R 4  each independently represent lower alkyl having 1 to 2 carbon atoms.   
     
     
       2. A compound of the formula ##STR7## where R 1  is as defined in claim 1. 
     
     
       3. A compound of the formula ##STR8## where R 2  is as defined in claim 1. 
     
     
       4. The compound of claim 2 which is 1,1-bis(4-pivaloylbenzyl)-3-methyl urea. 
     
     
       5. A composition for lowering lipid levels comprising a hypolipidemically effective amount of the compound of claim 1 and a pharmaceutically acceptable diluent or carrier therefor. 
     
     
       6. A method of treating lipidemia which comprises administering to a mammal in need of said treatment a hypolipidemically effective amount of a compound of claim 1.