Method of treating conditions of delayed hypersensitivity using bis-basic substituted acenaphthene derivatives

Abstract

Novel 3,6-bis basic ketone derivatives of acenaphthene useful in treating conditions of delayed hypersensitivity are disclosed.

I claim: 
     
       1. A method of treating conditions of delayed hypersensitivity which comprises administering to a patient in need thereof a 3,6-bis-basic ketone of acenaphthene having the formula: ##STR18## wherein A is a straight or branched alkylene chain having from 1 to 6 carbon atoms; and Y is the group ##STR19## wherein n is an integer of from 4 to 6, and R 3  is selected from the group consisting of hydrogen, lower alkyl having from 1 to 4 carbon atoms, phenyl and benzyl in which said R 3  group is linked to any of the heterocyclic carbon atoms; and pharmaceutically acceptable salts thereof in an amount effective to suppress delayed hypersensitivity. 
     
     
       2. A method of claim 1 wherein n is the integer 5. 
     
     
       3. A method of claim 2 wherein the compound is 3,6-bis(2-piperidinoacetyl)acenaphthene and pharmaceutically acceptable salts thereof.