Trans-octahydro-pyrido-indolo-benzazepine-3-alkanols, -alkanonitriles,-alkanoic acid and ester as tranquilizers

Abstract

Certain 3-substituted trans-octahydro-pyrido-pyrrolo-benzazepines are useful as major tranquilizers in warm-blooded animals or are useful as intermediates for producing such major tranquilizers.

I claim: 
     
       1. A compound of the following formula: ##STR28## provided that when R 1  = CH 3 , n = 1, or an acid addition salt thereof with a pharmaceutically suitable acid. 
     
     
       2. A compound of claim 1 wherein ##STR29## 
     
     
       3. A compound of claim 1 wherein ##STR30## 
     
     
       4. A compound of claim 1 wherein ##STR31## 
     
     
       5. A compound of claim 1 wherein ##STR32## 
     
     
       6. A compound of claim 1 wherein X = --c.tbd.n   n = 0-9   R 1  = h.   
     
     
       7. a compound of claim 1 wherein X = --c.tbd.n   n = 1   R 1  = ch 3 .   
     
     
       8. a compound of claim 1 wherein ##STR33## 
     
     
       9. A compound of claim 1 wherein ##STR34## 
     
     
       10. A pharmaceutical tranquilizing composition comprising of a pharmaceutically suitable carrier and an effective amount of a compound of claim 1. 
     
     
       11. A pharmaceutical tranquilizing composition comprising of a pharmaceutically suitable carrier and an effective amount of a compound of claim 2. 
     
     
       12. A pharmaceutical tranquilizing composition comprising of a pharmaceutically suitable carrier and an effective amount of a compound of claim 3. 
     
     
       13. A pharmaceutical tranquilizing composition comprising of a pharmaceutically suitable carrier and an effective amount of a compound of claim 4. 
     
     
       14. A pharmaceutical tranquilizing composition comprising of a pharmaceutically suitable carrier and an effective amount of a compound of claim 5. 
     
     
       15. A pharmaceutical tranquilizing composition comprising of a pharmaceutically suitable carrier and an effective amount of a compound of claim 6. 
     
     
       16. A pharmaceutical tranquilizing composition comprising of a pharmaceutically suitable carrier and an effective amount of a compound of claim 7. 
     
     
       17. A pharmaceutical tranquilizing composition comprising of a pharmaceutically suitable carrier and an effective amount of a compound of claim 8. 
     
     
       18. A pharmaceutical tranquilizing composition comprising of a pharmaceutically suitable carrier and an effective amount of a compound of claim 9. 
     
     
       19. A method for producing a tranquilizing effect in warm-blooded animals comprising administering to said warm-blooded animals an effective amount of a compound of claim 1. 
     
     
       20. A method for producing a tranquilizing effect in warm-blooded animals comprising administering to said warm-blooded animals an effective amount of a compound of claim 2. 
     
     
       21. A method for producing a tranquilizing effect in warm-blooded animals comprising administering to said warm-blooded animals an effective amount of a compound of claim 3. 
     
     
       22. A method for producing a tranquilizing effect in warm-blooded animals comprising administering to said warm-blooded animals an effective amount of a compound of claim 4. 
     
     
       23. A method for producing a tranquilizing effect in warm-blooded animals comprising administering to said warm-blooded animals an effective amount of a compound of claim 5. 
     
     
       24. A method for producing a tranquilizing effect in warm-blooded animals comprising administering to said warm-blooded animals an effective amount of a compound of claim 6. 
     
     
       25. A method for producing a tranquilizing effect in warm-blooded animals comprising administering to said warm-blooded animals an effective amount of a compound of claim 7. 
     
     
       26. A method for producing a tranquilizing effect in warm-blooded animals comprising administering to said warm-blooded animals an effective amount of a compound of claim 8. 
     
     
       27. A method for producing a tranquilizing effect in warm-blooded animals comprising administering to said warm-blooded animals an effective amount of a compound of claim 9.