Novel aminocyclitols and process for production thereof

Abstract

Novel beta -D-ribofuranosyl (1 -> 5), O-[ alpha -D-2-amino(or 2-acylamino)-2, 3-dideoxy-glucopyranosyl (1 -> 4) ] 1, 3-diamino (or 1, 3-diacylamino)-1, 2, 3-trideoxy-myoinositols and their acid salts. These compounds are useful either as antibiotics or as intermediates for their synthesis. The compound can be produced by treating an O- alpha -L-2, 6-diacylamino-2, 6-dideoxyidopyranosyl (1 -> 3), beta -D-ribofuranosyl (1 -> 5), O-[ alpha -D-2-acylamino-2, 3-dideoxy-glucopyranosyl (1 -> 4)] 1, 3-diacylamino-1, 2, 3-trideoxy-myoinositol with periodic acid or its salts, reacting the resulting compound with an amine, and optionally deacylating the product.

What we claim is: 
     
       1. β-D-ribofuranosyl (1→5), O-[α-D-2-amino (or 2-acylamino)-2,3-dideoxy-glucopyranosyl (1→4)] 1,3-diamino (or 1,3-diacylamino)-1,2,3-trideoxy-myoinositol of the following formula ##STR5## wherein R represents a member selected from the group consisting of hydrogen, acetyl, and an acid salt of said acetyl. 
     
     
       2. An acid salt of the compound of claim 1 in which the acid is a member selected from the group consisting of sulfuric, hydrochloric, carbonic, acetic, propionic, stearic or palmitic acid.