Disubstituted triphenylmethylmidazoles for treating mycotic infections

Abstract

Imidazoles of the formula ##STR1## and pharmaceutically acceptable nontoxic salts thereof, wherein X is methyl or chloro, Y is methyl or chloro, or, when Z is methyl or chloro, Y is hydrogen, and Z is methyl or chloro, or, when Y is methyl or chloro, Z is hydrogen, Are useful as antimycotics for the treatment of mycotic infections in humans and animals. The imidazoles may be produced by reacting the corresponding triphenylmethylcarbinol with a brominating or chlorinating agent and thereafter reacting the resultant triphenylmethyl halide, either with or without isolation, with imidazole in the presence or absence of an acid-binding agent, or they may be prepared by reacting a triphenylmethyl halide with imidazole, either in the presence or absence of an acid-binding agent.

What is claimed is: 
     
       1. A pharmaceutical composition for treating mycotic infections in humans and animals which comprises an anti-mycotically effective amount of 1-(2,6-dichlorophenyl-diphenyl)-methyl-imidazole or a pharmaceutically acceptable non-toxic salt thereof, in combination with a pharmaceutically acceptable non-toxic inert carrier. 
     
     
       2. A pharmaceutical composition for treating mycotic infections in humans and animals which comprises an anti-mycotically effective amount of 1-(2,3-dichlorophenyl-diphenyl)-methyl-imidazole or a pharmaceutically acceptable non-toxic salt thereof, in combination with a pharmaceutically acceptable non-toxic inert carrier. 
     
     
       3. A pharmaceutical composition for treating mycotic infections in humans and animals which comprises an anti-mycotically effective amount of 1-(2-chlorophenyl-2'-chlorophenyl)-methyl-imidazole or a pharmaceutically acceptable non-toxic salt thereof, in combination with a pharmaceutically acceptable non-toxic inert carrier. 
     
     
       4. A method of treating mycotic infections in humans and animals which comprises administering to a human or animal in need thereof an anti-mycotically effective amount of 1-(2,6-dichlorophenyl-diphenyl)-methyl-imidazole or a pharmaceutically acceptable non-toxic salt thereof, in combination with a pharmaceutically acceptable non-toxic inert carrier. 
     
     
       5. A method of treating mycotic infections in humans and animals which comprises administering to a human or animal in need thereof an anti-mycotically effective amount of 1-(2,3-dichlorophenyl-diphenyl)-methyl-imidazole or a pharmaceutically acceptable non-toxic salt thereof, in combination with a pharmaceutically acceptable non-toxic inert carrier. 
     
     
       6. A method of treating mycotic infections in humans and animals which comprises administering to a human or animal in need thereof an anti-mycotically effective amount of 1-(2-chlorophenyl-2'-chlorophenyl)-methyl-imidazole or a pharmaceutically acceptable non-toxic salt thereof, in combination with a pharmaceutically acceptable non-toxic inert carrier.