Dopamine hydroxylase inhibiting 2-amino-cyclopent-1-ene-1-thiocarboxylic acid-disulfides

Abstract

New 2-amino-cyclopent-1-ene-thiocarboxylic acid-disulfides of the formula, <IMAGE> (I) wherein R is a C1-6 alkyl group having optionally a C1-4 alkoxy, hydroxy, carboxy and/or amino substituent, a C2-4 alkenyl group, or a C3-8 cycloalkyl group, are prepared by oxidizing the respective 2-amino-cyclopent-1-ene-dithiocarboxylic acids of the formula, <IMAGE> (II) wherein R is as defined above. The compounds of the formula (I) exert dopamine- beta -hydroxylase inhibiting effects and can be applied in therapy.

What we claim is: 
     
       1. A 2-amino-cyclopent-1-ene-thiocarboxylic acid disulfide of the formula ##STR5## wherein R is C 1-6  alkyl or C 1-6  alkyl substituted with C 1-4  alkoxy, C 2-4  alkenyl or C 3-8  cycloalkyl group. 
     
     
       2. A compound selected from the group consisting of: 2-(N-butyl)-amino-cyclopent-1-ene-thiocarboxylic acid-disulfide,   2-(N-methoxyethyl)-amino-cyclopent-1-ene-thiocarboxylic acid-disulfide,   2-(N-cyclohexyl)-amino-cyclopent-1-ene-thiocarboxylic acid-disulfide,   2-(N-ethyl)-amino-cyclopent-1-ene-thiocarboxylic acid-disulfide, and   2-(N-allyl)-amino-cyclopent-1-ene-thiocarboxylic acid-disulfide.   
     
     
       3. 2-(N-butyl)-amino-cyclopent-1-ene-thiocarboxylic acid-disulfide. 
     
     
       4. 2-(N-methoxyethyl)-amino-cyclopent-1-ene-thiocarboxylic acid-disulfide. 
     
     
       5. 2-(N-cyclohexyl)-amino-cyclopent-1-ene-thiocarboxylic acid-disulfide. 
     
     
       6. 2-(N-ethyl)-amino-cyclopent-1-ene-thiocarboxylic acid-disulfide. 
     
     
       7. 2-(N-allyl)-amino-cyclopent-1-ene-thiocarboxylic acid-disulfide.