Piperidine and pyrrolidine alcohols

Abstract

This disclosure describes novel compounds of the formula: <IMAGE> where A is -CH2OH or <IMAGE> wherein R4 and R5 each independently represent hydrogen or lower alkyl having 1 to 2 carbon atoms or together with N represent <IMAGE> and, R1 is hydrogen or lower alkyl having 1 to 2 carbon atoms, and R2 and R3 each independently represent hydrogen, chloro, fluoro, methyl, methoxy or together, represent methylenedioxy, and n is 1 or 2, provided that one of R2 and R3 is other than hydrogen which are useful as hypolipidemic agents.

What is claimed is: 
     
       1. A compound of the formula ##STR14## wherein A is --CH 2  OH, and R 1  is hydrogen or lower alkyl having 1 to 2 carbon artoms, i.e., methyl or ethyl, and   R 2  and R 3  together represent methylenedioxy, and   n is 1 or 2, ora pharmaceutically acceptable acid addition salt thereof.   
     
     
       2. The compound of claim 1 which is 1-methyl-2-(3,4-methylenedioxyphenyl)-3-piperidinemethanol. 
     
     
       3. The compound of claim 1 which is 1-methyl-2-(3,4-methylenedioxyphenyl)-3-piperidinemethanol hydrochloride. 
     
     
       4. The compound of claim 1 which is 1-ethyl-2-(3,4-methylenedioxyphenyl)-3-piperidinemethanol. 
     
     
       5. The compound of claim 1 which is 1-ethyl-2-(3,4-methylenedioxyphenyl)-3-piperidinemethanol hydrochloride. 
     
     
       6. The compound of claim 1 which is 1-methyl-2-(3,4-methylenedioxyphenyl)-3-pyrrolidinemethanol. 
     
     
       7. The compound of claim 1 which is 1-methyl-2-(3,4-methylenedioxyphenyl)-3-pyrrolidinemethanol hydrochloride. 
     
     
       8. A method of treating lipidemia which comprises administering to a mammal in need of said treatment a hypolipidemically effective amount of a compound of claim 1. 
     
     
       9. A pharmaceutical composition for use in the treatment of lipidemia which comprises an effective amount of a compound of claim 1 and a pharmaceutically acceptable diluent or carrier therefor.