1,4-Dihydropyridine-3,5-dicarboxylic acid ester derivatives

Abstract

1,4-Dihydropyridine-3,5-dicarboxylic acid ester derivatives shown by the formula <IMAGE> wherein R represents a lower alkyl group and R' represents a hydrogen atom, a lower alkyl group or an aralkyl group, and the therapeutically non-toxic salts thereof. These compounds possess a vasodilative activity and an antihypertensive activity.

What is claimed is: 
     
       1. 1,4-Dihydropyridine-3,5-dicarboxylic acid ester derivatives represented by the formula ##STR25## wherein R represents a lower alkyl group and R' represents a hydrogen atom, a lower alkyl group, or benzyl phenylethyl, and the therapeutically non-toxic salts thereof. 
     
     
       2. 2,6-Dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid-3-(1-benzylpyrrolidin-3-yl)ester 5-methyl ester or the hydrochloride thereof as claimed in claim 1. 
     
     
       3. A compound as claimed in claim 1, wherein said salts are selected from the group consisting of the hydrochloride, sulfate, phosphate, acetate, fumarate, maleate, and tartrate. 
     
     
       4. An antihypertensive composition comprising a mixture of a 1,4-Dihydropyridine-3,5-dicarboxylic acid ester derivative represented by the formula ##STR26## wherein R represents a lower alkyl group and R' represents a hydrogen atom, a lower alkyl group, benzyl or phenylethyl, or a therapeutically non-toxic salt thereof as the active ingredient, and a therapeutically acceptable carrier therefor. 
     
     
       5. A composition as claimed in claim 4, comprising 2,6-Dimethyl-4-(3'nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid-3-(1-benzylpyrrolidin-3-yl)ester 5-methyl ester or the hydrochloride thereof as the active ingredient. 
     
     
       6. A method of treating hypertension comprising administering an antihypertensive effective amount of the composition of claim 4 or 5. 
     
     
       7. A method as claimed in claim 6, comprising administering by intravenous injection an amount of said composition to provide from 0.1 to 1 mg of said active ingredient per dose in an aqueous solution. 
     
     
       8. A method as claimed in claim 6, comprising orally administering an amount of said composition to provide from 5 to 20 mg of said active ingredient per dose.