Quinoxalinones useful for treating atopic eczema and urticaria

Abstract

Compounds of the formula below are useful for expanding the lumina of air passages in a mammal in need of said treatment. The compounds are also useful for treating atopic eczema and urticaria. ##STR1## wherein X and Y are the same or different and are hydrogen, fluoro, chloro, bromo, nitro, trifluoromethyl, alkyl of one to four carbon atoms, inclusive, alkoxy of one to four carbon atoms, inclusive, and cyano; R 1 is hydrogen, methyl or ethyl; R 2 is hydrogen, alkyl of one to six carbon atoms, inclusive, phenyl, benzyl, CH 2 Z wherein Z is fluoro, chloro, or bromo, CO 2 M, CH 2 CO 2 M, CH 2 CH 2 CO 2 M and CHR 3 CO 2 M wherein M is hydrogen, alkyl of one to four carbon atoms, inclusive, or a physiologically acceptable metal or amine cation and R 3 is alkyl of one to three carbon atoms, inclusive, with the proviso that M is not hydrogen when R 2 is CH 2 CO 2 M or CHR 3 CO 2 M.

We claim: 
     
       1. A method for treating atopic eczema or urticaria in a mammal in need of said treatment which comprises administering to said mammal an effective amount of a compound of the formula ##STR11## wherein X and Y are the same or different and are hydrogen, fluoro, chloro, bromo, nitro, trifluoromethyl, alkyl of one to four carbon atoms, inclusive, alkoxy of one to four carbon atoms, inclusive, or cyano; R 1  is hydrogen, methyl or ethyl,   R 2  is hydrogen, alkyl of one to six carbon atoms, inclusive, phenyl, benzyl,   CH 2  Z wherein Z is fluoro, chloro or bromo,   CO 2  M, CH 2  CO 2  M, CH 2  CH 2  CO 2  M or CHR 3  CO 2  M wherein M is hydrogen, alkyl of one to four carbon atoms, inclusive, or a physiologically acceptable metal or amine cation and R 3  is alkyl of one to three carbon atoms, inclusive, with the proviso that M is not hydrogen when R 2  is CH 2  CO 2  M or CHR 3  CO 2  M; in association with a pharmaceutical carrier.