Polymeric diffusion matrix containing phenylephrine

Abstract

There is disclosed a polymeric diffusion matrix for the sustained release of phenylephrine by transdermal delivery to a patient wherein the matrix comprises a polar plasticizer, polyvinylalcohol, polyvinylpyrrolidone, and a pharmaceutically effective amount of phenylephrine.

What is claimed is: 
     
       1. A self-supporting polymeric diffusion matrix for the sustained release of phenylephrine in order to transdermally deliver said phenylephrine to a patient and provide said patient with a decongestant effect, said matrix comprising from about 2 to about 60% of a polar plasticizer, from about 6 to about 20% by weight polyvinylalcohol, from about 2 to 10% by weight polyvinylpyrrolidone, and a pharmaceutically effective amount of phenylephrine to provide a sustained release of said phenylephrine over a prolonged period. 
     
     
       2. The polymeric diffusion matrix of claim 1 wherein said polar plasticizer is glycerol. 
     
     
       3. The polymeric diffusion matrix of claim 1 wherein said polyvinylalcohol has a molecular weight of about 50,000 to about 150,000. 
     
     
       4. The polymeric diffusion matrix of claim 1 wherein said polyvinylalcohol has a molecular weight of about 100,000 to about 150,000. 
     
     
       5. The polymeric diffusion matrix of claim 1 wherein said polyvinylpyrrolidone has a molecular weight of from about 15,000 to about 85,000. 
     
     
       6. The polymeric diffusion matrix of claim 1 wherein said polyvinylpyrrolidone has a molecular weight of about 20,000 to about 60,000. 
     
     
       7. The polymeric diffusion matrix of claim 1 wherein said polar plasticizer is polyethylene glycol present in an amount of about 2 to about 15% by weight. 
     
     
       8. The polymeric diffusion matrix of claim 1 wherein said polar plasticizer is a mixture of glycerol and polyethylene glycol wherein said polyethylene glycol is present in an amount by weight of from about 1 to about 5 parts per weight glycerol. 
     
     
       9. A method for the transdermal delivery of phenylephrine to a patient to provide said patient with a decongestant effect, comprising applying to said patient a selfsupporting diffusion matrix comprising from about 2 to about 60% by weight of a polar plasticizer, from about 6 to about 20% by weight polyvinylalcohol, from about 2 to about 10% by weight polyvinylpyrrolidone, and a pharmaceutically effective amount of phenylephrine to provide a sustained release of said phenylephrine over a prolonged period. 
     
     
       10. The method of claim 9 wherein said phenylephrine is present in an amount to provide sustained release of about 2 to about 50 mg per day.