1-Pyrrole- and 1-pyrrolidine-carboxylic acid derivatives and process for preparing the same

Abstract

1-Pyrrole- and 1-pyrrolidine-carboxylic acid derivatives corresponding to the general formula: ##STR1## in which R represents an alkyl radical having from 1 to 4 carbon atoms, preferably ethyl, and Am represents a group: ##STR2## wherein R 1 represents a 3-oxo-alkyl radical ##STR3## or a 3-oxo-alkenyl radical ##STR4## and R 2 represents hydrogen or R 1 and R 2 , when they are identical, each represent hydrogen, ##STR5## R 3 representing an alkyl radical having from 1 to 5 carbon atoms with the proviso that when R 1 and R 2 are simultaneously hydrogen, Am represents the group A. The novel derivatives are useful as intermediates for synthetizing azaprostaglandines.

We claim: 
     
       1. 2,5-Dihydro-1-pyrrole-carboxylic acid derivatives corresponding to the formula: ##STR18## wherein R represents an alkyl radical having from 1 to 4 carbon atoms, R 1  represents a 3-oxo-alkyl radical ##STR19## or a 3-oxo-alkenyl radical ##STR20## R 2  represents hydrogen or R 1  and R 2 , when they are identical, each represents ##STR21## R 3  representing an alkyl radical having from 1 to 5 carbon atoms. 
     
     
       2. Ethyl 3-(1'-pyrrolidinyl)-2,5-dihydro-1-pyrrole-carboxylate. 
     
     
       3. Ethyl 4-(3'-oxo-butyl)-3-(1'-pyrrolidinyl)-2,5-dihydro-1-pyrrole-carboxylate. 
     
     
       4. Ethyl 4-(3'-oxo-butyl)-3-oxo-1-pyrrolidine-carboxylate. 
     
     
       5. Ethyl 4-(3'-oxo-octyl)-3-(1'-pyrrolidinyl)-2,5-dihydro-1-pyrrole-carboxylate. 
     
     
       6. Ethyl 4-(3'-oxo-octyl)-3-oxo-1-pyrrolidine-carboxylate. 
     
     
       7. Ethyl 4-(3'-oxo-1'-octenyl)-3-(1'-pyrrolidinyl)-2,5-dihydro-1-pyrrole-carboxylate. 
     
     
       8. Ethyl 2,4-di-(3'-oxo-butyl)-3-(1'-pyrrolidinyl)-2,5-dihydro-1-pyrrole-carboxylate. 
     
     
       9. Ethyl 2,4-di-(3'-oxo-butyl)-3-oxo-1-pyrrolidine-carboxylate.