Novel carboxylic acids, benzoyl phenyl alkanoic acids and use thereof

Abstract

Novel carboxylic acids of the formula <IMAGE> I wherein Z is an aliphatic hydrocarbon chain selected from the group consisting of -(CH2)n- and -CH=CH-(CH2)n-2- where the double bond may be at any point in the chain, n is an integer from 5 to 10 and X, X1, X2 and X3 are individually selected from the group consisting of hydrogen, halogen, alkyl of 1 to 5 carbon atoms, alkoxy of 1 to 5 carbon atoms, alkylthio of 1 to 5 carbon atoms, CF3-, CF3O- and CF3S- and their non-toxic, pharmaceutically acceptable organic and inorganic salts and esters having analgesic and anti-inflammatory activity and their preparation.

We claim: 
     
       1. A compound selected from the group consisting of 6-[3'-(4-chlorobenzoyl)-2'-methyl-phenyl]-hexanoic acid and its non-toxic, pharmaceutically acceptable salts and esters. 
     
     
       2. An analgesic and anti-inflammatory composition comprising an effective amount of at least one compound of claim 1 and a pharmaceutically acceptable carrier. 
     
     
       3. A method of relieving pain and inflammation in human or animals comprising administering to human or animals an analgesically and anti-inflammatorilly effective amount of at least one compound of claim 1.