Treatment with dialkoxy pyridopyrimidines

Abstract

Potent psoriasis activity in combination with low inhibition of histamine N-methyltransferase has been found in a class of 2,4-diamino-6-(2,5-dialkoxybenzyl)-5-methylpyrido[2,3-d]pyrimidines.

We claim: 
     
       1. A method of treating psoriasis in a mammal suffering from psoriasis comprising the administration to said mammal of a non-toxic, effective antipsoriasis amount of a compound of formula (II): ##STR25## wherein R and R' are lower (C 1  -C 6 ) alkyl, or a pharmaceutically acceptable acid addition salt thereof. 
     
     
       2. A method of treating psoriasis in a mammal suffering from psoriasis comprising the administration to said mammal of a non-toxic, effective antipsoriasis amount of 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine. 
     
     
       3. The method of claim 1 or 2 in which the compound or salt is administered in a pharmaceutically acceptable carrier. 
     
     
       4. The method of claim 1 or 2 in which the compound or salt is administered as a part of a topical formulation. 
     
     
       5. The method of claim 1 or 2 in which the compound or salt is administered as a part of a topical formulation in which the compound or salt is at a concentration of 0.05 to 2% w/w. 
     
     
       6. The method of claim 1 or 2 in which the compound or salt is administered as part of an oral preparation or parenteral preparation. 
     
     
       7. The method of claims 1 or 2 in which the compound or salt is topically administered.