Heterocyclic substituted sulfonyl ureas, and their use

Abstract

What are disclosed are sulfonyl ureas of the formula <IMAGE> in which R1, X and Y are as defined in the specification, and their physiologically acceptable salts, pharmaceutical formulations on the basis of these compounds, and their use in the treatment of diabetes.

What is claimed is: 
     
       1. A sulfonyl urea of the formula ##STR12## or a physiologically acceptable salt thereof, wherein X is alkylene or alkenylene having from 3 to 6 carbon atoms, optionally substituted by up to 3 alkyl groups each having from 1 to 4 carbon atoms, or by phenyl; or the group ##STR13##  is a bicyclic system of the formula ##STR14##   and Y is alkylene having 2 or 3 carbon atoms;   R 1  is alkyl having from 4 to 6 carbon atoms, cycloalkyl, alkylcycloalkyl, dialkylcycloalkyl, cycloalkylalkyl, cycloalkenyl, or alkylcycloalkenyl in each case having 4 to 9 carbon atoms, or is methylcyclopentylmethyl, cyclohexenylmethyl, chlorocyclohexyl, methoxycyclohexyl, bicycloheptyl, bicycloheptenyl, bicycloheptylmethyl, bicycloheptenylmethyl, bicyclooctyl, nortricyclyl, adamantyl, or benzyl.   
     
     
       2. A compound as in claim 1 which is N-(4-[2-(3,4-dimethyl-2-oxo-3-pyrroline-1-carboxamido)-ethyl]-benzenesulfonyl)-N'-4-methyl-cyclohexyl-urea. 
     
     
       3. A compound as in claim 1 which is N-(4-[2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)-ethyl]-benzenesulfonyl)-N'-4-methyl-cyclohexyl-urea. 
     
     
       4. A compound as in claim 1 which is N-(4-[2-(3,4-dimethyl-2-oxo-3-pyrroline-1-carboxamido)-ethyl]-benzenesulfonyl)-N'-4-ethyl-cyclohexyl-urea. 
     
     
       5. A pharmaceutical composition for lowering the blood sugar level, which comprises a hypoglycemically effective amount of a sulfonyl urea or salt thereof as in claim 1 in combination with a pharmaceutically acceptable carrier therefor. 
     
     
       6. A method for lowering the blood sugar level in a patient suffering from diabetes, which comprises orally administering a hypoglycemically effective amount of a sulfonyl urea or salt thereof as claimed in claim 1.