US4414147AExpiredUtility

Methods of decreasing the hydrophobicity of fibroblast and other interferons

Assignee: MASSACHUSETTS INST TECHNOLOGYPriority: Apr 17, 1981Filed: Apr 17, 1981Granted: Nov 8, 1983

Est. expiryApr 17, 2001(expired)· nominal 20-yr term from priority

Inventors:Alexander M. Klibanov Robert S. Langer

A61K 38/215A61K 47/60

PatentIndex Score

186

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Claims

Abstract

A method for improving the stability and usefulness of interferon, including human fibroblast interferon, is disclosed. In this method, interferon is bonded to a non-hydrophobic substance to create a molecular complex that is less hydrophobic than untreated interferon.

Claims

exact text as granted — not AI-modified

We claim: 
     
       1. A method of reducing the hydrophobicity of interferon, comprising contacting said interferon with an anhydride of a dicarboxylic acid under conditions that allow said interferon to become bonded to said anhydride. 
     
     
       2. A method of claim 1 wherein said anhydride is selected from the following group: succinic anhydride, maleic anhydride, poly(ethylene maleic anhydride), and poly(ethylene succinic anhydride). 
     
     
       3. A composition of matter comprising a molecule of interferon that is bonded to an anhydride of a dicarboxylic acid.

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