Gastric cytoprotection with heterocyclic sulfonamides

Abstract

The present invention provides a method for gastrointestinal cytoprotection using a class of heterocyclic sulfonamides.

I claim: 
     
       1. A method of preventing a gastrointestinal inflammatory disease in a mammal with high susceptibility to the acquisition of said disease, which comprises: administering to said mammal systemically an amount effective to prevent the development of said disease of a compound selected from the group consisting of   N-methyl-2-benzothiazolesulfonamide;   5-(2-methylpropionamido)-1,3,4-thiadiazole-2-sulfonamide;   5-acetamido-1,3,4-thiadiazole-2-sulfonamide; and   6-ethoxy-2-benzothiazolesulfonamide.   
     
     
       2. A method of claim 1, wherein said mammal is a human. 
     
     
       3. A method of claim 2 wherein the compound is 5-acetamido-1,3,4-thiadiazole-2-sulfonamide (acetazolamide). 
     
     
       4. A method of claim 2 wherein the compound is 6-ethoxy-2-benzothiazolesulfonamide (ethoxzolamide). 
     
     
       5. A method of claim 2, wherein the compound is N-methyl-2-benzothiazolesulfonamide. 
     
     
       6. A method of claim 2, wherein the compound is 5-(2-methylpropionamido)-1,3,4-thiadiazole-2-sulfonamide;