Resorcin derivatives, process for their preparation and pharmaceutical compositions containing them

Abstract

The invention relates to new resorcin derivatives of the formula (I) <IMAGE> (I) wherein R1 and R2 independently represent hydrogen, halogen, trihalomethyl, alkyl having from one to 3 carbon atoms or alkoxy having from one to 3 carbon atoms. According to another aspect of the invention there are provided processes for the preparation of these compounds. The compounds of the formula (I) are pharmacologically active. In particular, they are suitable for the treatment of acute ethanolic intoxication. Pharmaceutical compositions containing them as active ingredient are also within the scope of the invention.

We claim: 
     
       1. A compound of the formula (I) ##STR6## wherein R 1  and R 2  independently represent hydrogen, halogen, trihalomethyl, alkyl having from one to 3 carbon atoms or alkoxy having from one to 3 carbon atoms. 
     
     
       2. A compound selected from the following group: 4-[1-(3-trifluoromethylphenyl)-1-hydroxypropyl]-resorcin,   4-[1-(2-trifluoromethylphenyl)-1-hydroxypropyl]-resorcin,   4-[1-(4-fluorophenyl)-1-hydroxypropyl]-resorcin,   4-[1-(2-methoxyphenyl)-1-hydroxypropyl]-resorcin,   4-[1-(4-chlorophenyl)-1-hydroxypropyl]-resorcin,   4-[1-(3-chlorophenyl)-1-hydroxypropyl]-resorcin,   4-[1-(2,5-dimethylphenyl)-1-hydroxypropyl]-resorcin, and   4-[1-(4-trifluoromethylphenyl)-1-hydroxypropyl]-resorcin.   
     
     
       3. A pharmaceutical composition containing a resorcin derivative of the formula (I) as claimed in claim 1, wherein R 1  and R 2  are as defined in claim 1, together with pharmaceutically acceptable carriers and/or auxiliary substances. 
     
     
       4. A method of treating acute ethanolic intoxication which comprises the step of administering to an affected subject an effective amount of a compound as defined in claim 1.