Orally effective inotropic compounds

Abstract

A method for increasing cardiac contractility in a warm-blooded animal suffering from acutely depressed cardiac contractility which comprises administering to said animal an effective amount of a compound of the formula <IMAGE> wherein R is hydrogen or isobutyrate, or a pharmaceutically acceptable acid addition salt thereof.

I claim: 
     
       1. A compound of the formula ##STR7## where R is hydrogen or isobutyrate, or a pharmaceutically acceptable acid addition salt thereof. 
     
     
       2. A compound according to claim 1, wherein R is hydrogen. 
     
     
       3. A compound according to claim 1, wherein R is isobutyrate. 
     
     
       4. A compound according to claim 1, N-[2-(3,4-dihydroxyphenyl)ethyl]-1-methyl-3-(3-carbamoylphenyl)propylamine hydrochloride. 
     
     
       5. A compound according to claim 1, N-[2-(3,4-diisobutyryl oxyphenyl)ethyl]-1-methyl-3-(3-carbamoylphenyl)propylamine hydrochloride. 
     
     
       6. A method for increasing cardiac contractility in a warm-blooded animal suffering from depressed cardiac contractility which comprises administering to said animal an effective amount of a compound of the formula ##STR8## wherein R is hydrogen or isobutyrate, or a pharmaceutically acceptable acid addition salt thereof. 
     
     
       7. A method according to claim 6, wherein R is hydrogen and the compound is administered orally. 
     
     
       8. A method according to claim 6, wherein R is isobutyl and the compound is administered buccally. 
     
     
       9. A method according to claim 6, wherein R is hydrogen and the compound is administered intravenously. 
     
     
       10. A method according to claim 6, wherein R is isobutyl and the compound is administered orally. 
     
     
       11. A pharmaceutical composition in dosage unit form which comprises a dosage effective for the treatment of depressed cardiac contractility of a compound of the formula ##STR9## or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. 
     
     
       12. A pharmaceutical composition in dosage unit form which comprises a dosage effective for the treatment of depressed cardiac contractility of a compound of the formula ##STR10## or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.