Hydroxamic acid and pharmaceutical preparations containing the same

Abstract

Hydroxamic acids, pharmaceutical preparations containing the same, new ω(2'-naphthoxy)-alkylhydroxamic acids as well as a process for their production are disclosed. The new compounds display antiasthmatic and further pharmacologically valuable characteristics. They are prepared by reacting the corresponding carboxylic acid ester or amide with hydroxylamine or its salt under the described conditions into compounds of Formula I, R--CO--NH--OH. The compounds of Formula I are useful in human and veterinary medicine as medicaments the active principal of which is the inhibition of lipoxygenase, thus as antiasthmatic, antianaphylactic, antiphlogistic, antirheumatic and antithrombotic preparations.

What is claimed as new and desired to be protected by Letters Patent is set forth in the appended claims. 
     
       1. A method of treating bronchial asthma, asthmatic bronchitis, lung emphysema, allergic illnesses, inflammatory disease, or thromboses, by inhibiting the activity of lipoxygenase, which comprises the step of administering to an animal subject in need of said treatment a pharmaceutically effective amount of a compound of the Formula (I)   R--CO--NH--OH     in which   R is 2-hydroxyphenyl, 2-hydroxy-1-naphthyl, 1-hydroxy-2-naphthyl, 2-hydroxy-3-naphthyl, 2-amino-phenyl or an ω(1'-naphthoxy)-alkyl or an ω(2'-naphthoxy)-alkyl of the Formula (II) ##STR5## in which R 1  is a C 1  to C 10  straight or branched alkyl group, or a phenyl or a substituted phenyl group, and n is 1; or R 1  is hydrogen, and n is 1 to 10.   
     
     
       2. The method of treatment defined in claim 1 wherein the compound of the Formula (I) is administered orally. 
     
     
       3. The method of treatment defined in claim 2 wherein the compound of the Formula (I) is administered as an aerosol. 
     
     
       4. A method of treating bronchial asthma, asthmatic bronchitis, lung emphysema, allergic illnesses, inflammatory diseases, or thromboses by inhibiting the activity of lipoxygenase, which comprises the step of administering to an animal subject in need of said treatment a pharmaceutically effective amount of a compound of Formula (III) ##STR6## wherein R 2  is a straight or branched alkyl with 3 to 10 carbon atoms or is substituted phenyl, and n is 1; or R 2  is hydrogen, and n is 4 to 9.