N-[4-[ω-(4-acyl-3-hydroxyphenoxy)alkoxy]-phenyl]1H-tetrazole-5-carboxamides and use thereof as anti-allergics

Abstract

There are described compounds of the formula <IMAGE> (I) in which R1 is hydrogen or C1-6 alkyl, R2 is hydrogen, C1-6 alkyl or C3-6 alkenyl, R3 is hydrogen or C1-6 alkyl, R4 is hydrogen or an N-protecting group, n is 2, 3, 4 or 5, and X is oxygen, sulphur or -CH2-, provided that when X is -CH2- n is 0; and salts thereof. The compounds in which R4 is hydrogen have pharmaceutical activity.

We claim: 
     
       1. A compound of the formula ##STR12## in which R 1  is hydrogen or C 1-6  alkyl, R 2  is hydrogen, C 1-6  alkyl or C 3-6  alkenyl, R 3  is hydrogen or C 1-6  alkyl, R 4  is hydrogen, n is 2, 3, 4 or 5, and X is oxygen or sulphur; or a pharmaceutically acceptable salt thereof. 
     
     
       2. A compound according to claim 1, in which X is oxygen and n is 2, 3, 4 or 5. 
     
     
       3. A compound according to claim 2 in which R 1  is C 1-4  alkyl, R 2  is C 1-4  alkyl and R 3  is hydrogen. 
     
     
       4. N-{4-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenyl}-1H-tetrazole-5-carboxamide. 
     
     
       5. A pharmaceutical formulation comprising a compound according to claim 1 or a pharmaceutically-acceptable salt thereof associated with a carrier or diluent. 
     
     
       6. A method of treating a mammal, including a human, suffering from an immediate hypersensitivity disease, which comprises administering to the mammal an effective amount of a compound as defined in claim 1 or a pharmaceutically-acceptable salt thereof. 
     
     
       7. A compound of the formula ##STR13## in which R 1  is hydrogen or C 1-6  alkyl, R 2  is hydrogen, C 1-6  alkyl or C 3-6  alkenyl, R 3  is hydrogen or C 1-6  alkyl, R 4  is benzyl or 4-methoxybenzyl, n is 2, 3, 4 or 5, and X is oxygen or sulphur.