Anti-peptic ulcer agent

Abstract

Use of a compound of the formula: <IMAGE> wherein R is hydrogen atom or ethyl group, or a pharmaceutically acceptable salt thereof for prophylaxis and/or treatment of peptic ulcer, and a method for prophylaxis and/or treatment of peptic ulcer disease which comprises administering an effective amount of the above-mentioned compound to warm blooded aninal, especially human. Said active compounds have excellent pharmacological activities such as inhibition of ulceration and inhibition of gastric secretion, and hence, are useful as an anti-peptic ulcer agent.

What is claimed is: 
     
       1. A method for treating peptic ulcer disease in a warm blooded mammal in need of such treatment which comprises orally or parenterally administering to said mammal an anti-peptic ulcer effective amount of a compound of the formula: ##STR3## wherein R is a hydrogen atom or an ethyl group, or a pharmaceutically acceptable salt thereof. 
     
     
       2. The method of claim 1, wherein the active compound is a compound of the formula [I] wherein R is ethyl group. 
     
     
       3. The method of claim 2, wherein the active compound is in the form of dihydrochloride. 
     
     
       4. The method of claim 2, wherein the active compound is in the form of dimaleate. 
     
     
       5. The method of claim 1, wherein the active compound is a compound of the formula [I] wherein R is hydrogen atom. 
     
     
       6. The method of claim 5, wherein the active compound is in the form of monomaleate. 
     
     
       7. The method of claim 1, wherein the active compound is administered in the form of a pharmaceutical preparation for oral or parenteral administration. 
     
     
       8. The method of claim 7, wherein the preparation is administered in oral route. 
     
     
       9. The method of claim 1, wherein the active compound is administered in a dose of 0.01 to 20 mg/kg/day. 
     
     
       10. A method for treating peptic ulcer disease in a warm blooded mammal in need of such treatment which comprises orally administering to said mammal 2-(4-ethyl-1-piperazinyl)-4-phenylquinoline dimaleate in a dose of 0.01 to 20 mg/kg/day. 
     
     
       11. A method for treating peptic ulcer disease in a warm blooded mammal in need of such treatment which comprises orally administering to said mammal 2-(1-piperazinyl)-4-phenylquinoline monomaleate in a dose of 0.01 to 20 mg/kg/day.