1-phenyl-3-benzazepines and their use for treating gastrointestinal motility disorders

Abstract

1-Phenyl-3-benzazepine compounds are useful in treating gastrointestinal motility disorders. A particular compound of this invention is 8-hydroxy-3-methyl-1-phenyl-7-phenylthio-2,3,4,5-tetrahydro-1H-3-benzazepine.

What is claimed is: 
     
       1. A compound of the formula: ##STR4## in which: R 1  is hydrogen, lower alkyl or C 3  -C 5  alkenyl; R 2  is hydrogen, hydroxy, lower alkoxy, halogen, trifluoromethyl, lower alkyl, SO n  lower alkyl, SO n  CF 3 , SO n  phenyl or SO 2  NR 6  R 7  ;   R 3  is hydrogen, lower alkyl or lower alkanoyl;   R 4  is SO n  R 5  or SO 2  NR 6  R 7  ;   n is 0, 1 or 2;   R 5  is ##STR5##  or trifluoromethyl; and R 6  and R 7  are hydrogen or lower alkyl or a pharmaceutically acceptable acid addition salt thereof.   
     
     
       2. A compound of claim 1 in which R 3  O is in the 8-position. 
     
     
       3. A compound of claim 1 in which R 3  O is in the 8-position and R 4  is in the 7-position. 
     
     
       4. A compound of claim 1, 2, or 3 in which R 1  is hydrogen or methyl, R 2  is hydrogen, hydroxy, SO n  lower alkyl, SO n  CF 3 , SO n  phenyl or SO n  NR 6  R 7 , R 3  is hydrogen and R 4  is SO n  R 5  or SO 2  NH 2 . 
     
     
       5. A compound of claim 1 said compound being 8-hydroxy-3-methyl-1-phenyl-7-phenylthio-2,3,4,5-tetrahydro-1H-3-benzazepine. 
     
     
       6. A compound of claim 1 said compound being 8-hydroxy-1-phenyl-7-trifluoromethylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine. 
     
     
       7. A compound of claim 1 said compound being 8-hydroxy-1-phenyl-7-sulfamoyl-2,3,4,5-tetrahydro-1H-3-benzazepine. 
     
     
       8. A pharmaceutical composition for treatment of gastrointestinal motility disorders comprising a pharmaceutical carrier and, in an amount sufficient to produce said activity, a compound of claim 1. 
     
     
       9. A method of treating gastrointestinal motility disorders which comprises administering internally to a subject in need of said treatment an effective amount of a compound of claim 1. 
     
     
       10. A method of claim 9 in which gastroesophageal reflux disease or delayed gastric emptying is treated.