(5R,6S,8R)-6-(1-hydroxyethyl)-2-(3R-pyrrolidin-2-one-3-yl)thiopenem-3-carboxylic acid

Abstract

There is disclosed the compound (5R,6S,8R)-6-(1-hydroxyethyl)-2-(3R-pyrrolidin-2-one-3-yl)thiopenem-3- carboxylic acid, and pharmaceutically acceptable salts and esters as well as compositions containing them and methods for their use.

We claim: 
     
       1. (5R,6S,8R)-6-(1-hydroxyethyl)-2-(3R-pyrrolidin-2-one-3-yl)thiopenem-3-carboxylic acid, the pharmaceutically acceptable salts and pharmaceutically acceptable esters thereof. 
     
     
       2. A compound of claim 1 wherein the pharmaceutically acceptable salt is an alkali metal salt. 
     
     
       3. A compound of claim 2 wherein the alkali metal is sodium. 
     
     
       4. A compound of claim 1 wherein the pharmaceutically acceptable salt is an alkaline earth metal salt. 
     
     
       5. A compound of claim 1 wherein the pharmaceutically acceptable salt is an amine salt. 
     
     
       6. A compound of claim 1 wherein the pharmaceutically acceptable esters are metabolizable esters. 
     
     
       7. An antibacterially effective pharmaceutical composition comprising an antibacterial effective amount of a compound of claim 1 in admixture with a pharmaceutically acceptable carrier therefor. 
     
     
       8. A composition according to claim 7 adapted for oral administration. 
     
     
       9. A composition according to claim 7 adapted for parenteral administration. 
     
     
       10. A composition according to claim 7 adapted for topical administration. 
     
     
       11. A method of treating or preventing susceptible bacterial infections which comprises administering to a host in need of such treatment or prevention a compound of claim 1 or a pharmaceutical composition thereof in an amount sufficient to treat or prevent such infection. 
     
     
       12. A method according to claim 11 wherein the route of administration is oral. 
     
     
       13. A method according to claim 11 wherein the route of administration is parenteral. 
     
     
       14. A method according to claim 11 wherein the route of administration is topical.