4-alkoxy-pyrido[2,3-d]pyrimidine derivatives for treatment of myocardiac ischemia

Abstract

4-Alkoxy-pyrido[2,3-d]pyrimidine derivatives are described as well as processes for their preparation. For reason of their vasospasmolytic effects these compounds are mainly indicated for the treatment of cerebral, cardiac, and peripheral vascular diseases such as myocardiac ischemia, cerebral infarction, pulmonary thromboses, as well as in cases of arterioschlerosis and other stenotic disorders. They are therefore valuable agents for combating cardiovascular mortality.

We claim: 
     
       1. A metod for treating myocardiac ischemia which comprises administering to a host suffering therefrom a pharmaceutical composition in unit dosage form comprising a calcium antagonist effective amount of a compound of the formula ##STR5## wherein R 1  is phenyl, pyridyl or thienyl, or phenyl substituted by up to three of the same or different groups selected from a straight or branched alkyl with up to four carbon atoms, halogen, nitro, a straight or branched alkoxy with up to four carbon atoms, difluoromethoxy, trifluromethoxy, diloweralkylamino, loweralklthio or trifluoromethyl or a methylenedioxy group; R 2  represents a nitrile group, a carboxyl group or an alkoxycarbonyl residue with up to six carbon atoms; R 3  is a straight-chained or branched alkyl group with up to four carbon atoms or an amino group; and R 4  represents a straight-chained or branched alkyl group with up to four carbon atoms; or a pharmaceutically acceptable salt thereof with a pharmaceutically acceptable carrier in diluent.