Method for the preparation of feed premix in compositions of maduramicin

Abstract

A method for the preparation of feed premix compositions of the antibiotic maduramicin which have improved stability of the antibiotic at elevated temperatures and the stable feed premix compositions prepared thereby.

What is claimed is: 
     
       1. A method for improving the stability of feed premix compositions of maduramicin at elevated temperatures comprising ammoniation of an edible carrier to a pH of greater than about pH 7.1, and admixing the ammoniated carrier with a solution of maduramicin or the ammonium salt thereof in a physiologically acceptable alcohol. 
     
     
       2. A method according to claim 1, wherein the ammoniating agent is gaseous ammonia, ammonium hydroxide, ammonium salts of weak acids, or a mixture thereof. 
     
     
       3. A method according to claim 2, wherein an edible carrier is ammoniated with gaseous ammonia. 
     
     
       4. A feed premix composition of maduramicin and an edible carrier which is stable at elevated temperatures, comprising (a) an edible carrier which has been ammoniated to raise its pH to over about pH 7.1, which is admixed with   (b) a compound selected from the group consisting of maduramicin, the ammonium salt of maduramicin and mixtures thereof in a   (c) physiologically acceptable alcohol.   
     
     
       5. An improved maduramicin feed premix composition wherein the improvement consists of increasing the stability of said composition at elevated temperatures by ammoniating an edible carrier to a pH≧ about 7.1 prior to admixing the ammoniated carrier with a solution of maduramicin or the ammonium salt thereof in a physiologically acceptable alcohol.