Aci-reductone compounds belonging to the 6,7-disubstituted-3,4-dihydro benzopyan-2H-one class having antiaggregatory properties

Abstract

The present invention relates to novel benzopyranone aci-reductone compounds of the formula I wherein X and Y are selected from the group comprising H (except that X and Y are not both H, unless otherwise indicated) Cl or other halogen, OH, a straight or branched C 1 -C 6 alkyl or alkoxy group or phenyl or phenyloxy groups, such as, for example a phenyl or a tertiary butyl group. The invention also provides for compounds of the general formula I wherein X, Y=OCH 2 O. ##STR1## The compounds of the invention are useful in the treatment or prevention of thromboembolic disorders.

We claim: 
     
       1. A benzopyanone aci-reductone compound selected from the group consisting of the compounds of formula I: ##STR15## wherein X and Y are selected from the group consisting of H, OH, halogen, a straight or branched C 1  -C 6  alkoxy group, phenyl and phenyloxy group, and X, Y is OCH 2  O, provided that X and Y are not both selected from the group consisting of H and OH; or a physiologically acceptable salt thereof. 
     
     
       2. A benzopyanone aci-reductone compound selected from the group consisting of the compounds of formula I: ##STR16## wherein X is a hydrogen atom and Y is a chlorine atom, or a physiologically acceptable salt thereof. 
     
     
       3. A benzopyanone aci-reductone compound selected from the group consisting of the compounds of formula I: ##STR17## wherein X is a hydrogen atom and Y is a phenyl group, or a physiologically acceptable salt thereof. 
     
     
       4. A benzopyranone aci-reductone compound selected from the group consisting of the compounds of formula I: ##STR18## wherein X, Y is a OCH 2  O group, or a physiologically acceptable salt thereof. 
     
     
       5. The compound of the formula ##STR19## wherein X is H and Y is Cl, 6-chloro-3,4-dihydroxy-2H-1-benzopyran-2-one or its physiologically acceptable salt. 
     
     
       6. The compound of the formula ##STR20## wherein X is H and Y is Ph, 6-phenyl-3,4-dihydroxy-2H-1-benzopyran-2-one or its physiologically acceptable salt. 
     
     
       7. The compound of the formula ##STR21## wherein X, Y is an OCH 2  O group, 6,7-methylenedioxy-3,4-dihydroxy-2H-1-benzopyran-2-one or its physiologically acceptable salt. 
     
     
       8. The compound of the formula ##STR22## wherein X is a tertiary butyl and Y is OH, 6-hydroxy-7-tert-butyl-3,4-dihydroxy-2H-1-benzopyran-2-one or its physiologically acceptable salt. 
     
     
       9. An antiaggregatory composition comprising an effective amount of a compound selected from the group consisting of compounds of formula I ##STR23## wherein X and Y are selected from a group consisting of H, OH, halogen, a straight or branched C 1  -C 6  alkyl or alkoxy group, phenyl and phenyloxy group, and X and Y is OCH 2  O, provided that X and Y are not both selected from the group consisting of H, and OH; or a physiologically acceptable salt thereof together with a physiologically acceptable carrier or excipient. 
     
     
       10. An antiaggregatory composition comprising an effective amount of compound of formula I ##STR24## wherein X is a hydrogen atom and Y is a hydrogen atom or a physiologically acceptable salt thereof together with a physiologically acceptable carrier or excipient. 
     
     
       11. An antiaggregatory composition comprising an effective amount of compound of formula I ##STR25## wherein X is a hydrogen atom and Y is a chlorine atom or a physiologically acceptable salt thereof together with a physiologically acceptable carrier or excipient. 
     
     
       12. An antiaggregatory composition comprising an effective amount of compound of formula I ##STR26## wherein X is a hydrogen atom and Y is a phenyl group or a physiologically acceptable salt thereof together with a physiologically acceptable carrier or excipient. 
     
     
       13. An antiaggregatory composition comprising an effective amount of compound of formula I ##STR27## wherein X, Y is an OCH 2  O group or a physiologically acceptable salt thereof together with a physicologically acceptable carrier or excipient. 
     
     
       14. An antiaggregatory composition comprising an effective amount of compound of formula I ##STR28## wherein X is a tertiary butyl group and Y is an OH group or a physiologically acceptable salt thereof together with a physicologically acceptable carrier or excipient.