Amine derivative and its salt and anti-ulcer agent containing the same

Abstract

This invention relates to a novel compound represented by the formula: <IMAGE> wherein R is a 4-hydroxyphenyl group, a 4-carbamoylphenyl group or a 3-methanesulfonylaminophenyl group and its salt, which have an excellent anti-ulcer effect and good stability, to a process for producing the same, and to an anti-ulcer agent containing the same.

What is claimed is: 
     
       1. An amine derivative represented by the formula: ##STR11## wherein R is a 4-hydroxyphenyl group, a 4-carbamoylphenyl group or a 3-methanesulfonylaminophenyl group, or its salt. 
     
     
       2. An amine derivative or its salt according to claim 1, wherein R is a 4-hydroxyphenyl group. 
     
     
       3. An amine derivative or its salt according to claim 1, wherein R is a 4-carbamoylphenyl group. 
     
     
       4. An amine derivative or its salt according to claim 1, wherein R is a 3-methanesulfonylaminophenyl group. 
     
     
       5. An anti-ulcer composition, comprising an effective amount of an amine derivative represented by the formula: ##STR12## wherein R is a 4-hydroxyphenyl group, a 4-carbamoylphenyl group or a 3-methanesulfonylaminophenyl group or its salt and a pharmaceutically acceptable carrier or diluent. 
     
     
       6. An anti-ulcer composition according to claim 5, wherein R is a 4-hydroxyphenyl group. 
     
     
       7. An anti-ulcer composition according to claim 5, wherein R is a 4-carbamoylphenyl group. 
     
     
       8. An anti-ulcer composition according to claim 5, wherein R is a 3-methanesulfonylaminophenyl group. 
     
     
       9. A method for treating a patient with a peptic ulcer, comprising administering a therapeutically effective amount of an amine derivative represented by the formula: ##STR13## wherein R is a 4-hydroxyphenyl group, a 4-carbamoylphenyl group, or a 3-methanesulfonylaminophenyl group, or its salt. 
     
     
       10. The method according to claim 9, wherein R is a 4-hydroxyphenyl group. 
     
     
       11. The method according to claim 9, wherein R is a 4-carbamoylphenyl group. 
     
     
       12. The method of claim 9, wherein R is a 3-methanesulfonylaminophenyl group.