Carvone enhancement of transdermal drug delivery

Abstract

Disclosed herein are compositions and methods for enhancing the transdermal delivery of physiologically active agents across mammalian skin or membranes and which comprise a percutaneous transfer enhancing amount of 1-carvone and a drug.

What is claimed is: 
     
       1. A composition for the transdermal delivery of physiologically active agents to mammals by topical administration comprising an effective amount of a systemically active, water soluble or solubilizable drug, a percutaneous transfer enhancing amount of 1-carvone and a pharmaceutically acceptable vehicle comprising at least one pharmaceutically acceptable solvent or solubilizer for said 1-carvone, said enhancing amount of 1-carvone comprising by weight about 5% to about 16% of the composition. 
     
     
       2. The composition of claim 1 in which the pharmaceutically acceptable vehicle further comprises at least one pharmaceutically acceptable solvent for the drug. 
     
     
       3. The composition of claim 2 in which the solvents for each of the drug and the 1-carvone are in the amounts employed, at least partially miscible with each other. 
     
     
       4. A method for enhancing the transfer of physiologically active agents through mammalian skin and membranes comprising topically administering to substantially the same section of mammalian skin or membrane an effective amount of a systemically active, water soluble or solubilizer drug, a percutaneous transfer enhancing amount of 1-carvone and a pharmaceutically acceptable vehicle. 
     
     
       5. The method of claim 4 wherein said drug and said percutaneous transfer amount of 1-carvone are supplied to said mammal sequentially. 
     
     
       6. The method of claim 4 wherein said drug and said percutaneous transfer amount of 1-carvone are supplied to said mammal simultaneously. 
     
     
       7. The method of claim 4 wherein the 1-carvone is soluble in said vehicle. 
     
     
       8. The method of claim 4 wherein the 1-carvone is soluble in said vehicle and the drug is at least partially soluble in said vehicle. 
     
     
       9. The method of claim 4 wherein each of the drug and the 1-carvone are comprised in separate solubilizing compositions therefor and each of said compositions are substantially miscible with the other of said compositions and wherein at least one of said compositions contains said pharmaceutically acceptable vehicle. 
     
     
       10. A topical composition for the transdermal delivery of physiologically active agents to mammals comprising an effective amount of a systemically active, water soluble or solubilizable drug selected from the group consisting of albuterol and hydrocortisone, a percutaneous transfer enhancing amount of 1-carvone and a pharmaceutically acceptable vehicle comprising at least one pharmaceutically acceptable solvent or solubilizer for said 1-carvone, said enhancing amount of 1-carvone comprising by weight about 5% to about 16% of the composition. 
     
     
       11. A method for enhancing the transfer of physiologically active agents through mammalian skin and membranes comprising topically administering to substantially the same section of mammalian skin or membrane an effective amount of a systemically active, water soluble or solubilizable drug selected from the group consisting of albuterol and hydrocortisone, a percutaneous transfer enhancing amount of 1-carvone and a pharmaceutically acceptable vehicle.