1-hydroxy-3-(N-methyl-N-propylamino)propane-1,1-diphosphonic acid, pharmaceutical compositions and methods of use

Abstract

The present invention provides 1-Hydroxy-3-(N-methyl-N-propylamino)propane-1,1-diphosphonic acid of formula ##STR1## wherein R is hydrogen or C 1 -C 4 alkyl and the pharmacologically acceptable salts thereof. The present invention also provides processes for the preparation of a diphosphonic acid of formula I and pharmaceutical compositions containing it for the treatment of diseases of the calcium metabolism.

What is claimed is: 
     
       1. A diphosphonate compound of the formula ##STR9## wherein R is hydrogen, and the pharmacologically acceptable salts thereof. 
     
     
       2. A pharmaceutical composition for the treatment or prophylaxis of calcium metabolism disturbance or disease containing an effective amount of at least one compound of claim 1 in pharmaceutically acceptable carrier. 
     
     
       3. A pharmaceutical composition for the treatment or prophylaxis of calcium metabolism disturbance or disease containing an effective amount in a pharmaceutically acceptable carrier of 1-hydroxy-3-(N-methyl-N-propylamino)propane-1,1-diphosphonic acid. 
     
     
       4. A method for the treatment or prophylaxis of calcium metabolism disturbance or disease comprising administering a pharmaceutically effective amount of the compound of claim 1. 
     
     
       5. A method for the treatment or prophylaxis of calcium metabolism disturbance or disease comprising administering a pharmaceutically effective amount of 1-hydroxy-3-(N-methyl-N-propylamino)propane-1,1-diphosphonic acid. 
     
     
       6. The method of claim 4 wherein 0.001-10 mg P/Kg of the pharmaceutically acceptable diphosphonate compound are administered per day. 
     
     
       7. The method of claim 5 wherein 0.01-10 mg P/Kg of the pharmaceutically acceptable disphosphonate are administered per day.