Anti-bacterial T-cell factor

Abstract

A method of protecting a mammal against a pathogenic bacterium by administering a soluble suppressor T-cell factor derived from a mammal that has been immunized with the bacterium or an antigenic surface fragment of the bacterium. Also disclosed are a hybrid cell fusion of an immunized suppressor T cell, methods of making such cells, and method of producing soluble suppressor T-cell factors.

What is claimed is: 
     
       1. A hybrid cell producing a water-soluble factor, wherein said factor protects against formation of abscesses caused by Bacteroides fragilis bacterium, said cell comprising a fusion product of: (1) a suppressor T cell from a mammal immunized with said bacterium or a capsular polysaccharide thereof; and   (2) a thymoma cell.   
     
     
       2. The hybrid cell of claim 1 wherein said mammalian suppressor T cell is a rat or mouse cell. 
     
     
       3. The hybrid cell of claim 1 wherein said bacterium is from the species B. fragilis. 
     
     
       4. The hybrid cell of claim 1 wherein said thymoma cell is derived from cell line BW ATCC 5147. 
     
     
       5. The hybrid cell of claim 1 wherein said hybrid cell is identical to or subcloned from the deposit designated ATCC HB 8004.