Palatable ibuprofen solutions

Abstract

Palatable ibuprofen aqueous base solutions are described which contain dissolved therein ibuprofen and hydroxypropyl beta cyclodextrin, which form an inclusion complex, and sweeteners to mask the sour taste common to organic acids.

We claim: 
     
       1. A palatable aqueous base ibuprofen solution suitable for oral administration having a pH of about 3 to 5 comprising about 2% to 5% weight ibuprofen by volume of the total composition, about 20% to about 70% weight by volume of at least one taste masking sweetening ingredient and about 22% to about 75% weight by volume of hydroxypropyl beta cyclodextrin having a degree of hydroxpropyl substitution of about 6 to about 7.5, the weight ratio of ibuprofen to hydroxypropyl beta cyclodextrin being 1:11 to 1:15, and water qs to 100% by volume of the composition. 
     
     
       2. The palatable aqueous base ibuprofen composition of claim 1 containing about 2% weight ibuprofen by volume of the total composition and additionally containing about 0.30% weight by volume of pseudoephedrine hydrochloride. 
     
     
       3. The palatable aqueous base ibuprofen composition of claim 2 additionally containing about 0.15% weight by volume of dextromethorphan hydrobromide. 
     
     
       4. The palatable aqueous base ibuprofen composition of claim 2 additionally containing about 0.125% weight by volume of diphenhydramine hydrochloride. 
     
     
       5. The palatable aqueous base ibuprofen composition of claim 1 wherein the taste masking sweetening ingredient is selected from the group consisting of at least one of sodium saccharin, aspartame, sucrose, glycerin, sorbitol, and sorbitol solution.