Pharmaceutically active basic nitro-phenyl-dihydropyridine amides

Abstract

Hypertension and cardiac insufficiency can be controlled by 4-nitrophenyl-dihydropyridine amides of the formula <IMAGE> in which X can be ethylene or the like, Y is pyridyl or -NR9R10, and R9 and R10 each independently is hydrogen or an organic group, or together form a ring, and physiologically tolerated salts thereof. Compounds in which R5 and R6 are not aryl or aralkyl are new.

What is claimed is: 
     
       1. A method of controlling cardiac arrhythmias in a patient in need thereof which comprises administering to such patient an amount effective therefor of a 4-nitrophenyldihydropyridine amide of the formula ##STR61## in which R 1  and R 2  are identical or different and each represent hydrogen, alkyl with 1 to 4 carbon atoms, cyclopropyl or cyclopentyl, R 3  and R 4  represent methyl,   X represents straight-chain or branched alkyl with up to 4 carbon atoms, and   Y represents pyridyl or morpholino or represents a group of the formula NR 9  R 10  in which   R 9  and R 10  are identical or different and represent hydrogen, alky with up to 4 carbon atoms or benzyl.   
     
     
       2. The method according to claim 1, wherein such compound is N-cyclopropyl 3-(2-N-benzyl-N-methyl-ethoxycarbonyl)-1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-pyridine-5-carboxamide of the formula ##STR62## or a physiologically tolerated salt thereof. 
     
     
       3. The method according to claim 1, wherein such compound is N-propyl 3-(2-N-benzyl-N-methyl-ethoxycarbonyl)-1,4-dihydro-2,6-dimethyl-4-(2-nietrophenyl)-pyridine-5-carboxamide of the formula ##STR63## or a physiologically tolerated salt thereof. 
     
     
       4. The method according to claim 1, wherein such compound is N-ethyl-3-(2N-benzyl-N-methyl-ethoxycarbonyl)-1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-pyridine-5-carboxamide of the formula ##STR64## or a physiologically tolerated salt thereof.