Topical therapeutic system comprising 5-fluorouracil

Abstract

The present invention relates to a superficial therapeutic system consisting of an impermeable backing layer, an active substance containing matrix, and a removable protective layer, in which the matrix comprises: a. antineoplastic active substance b. a self-adhesive polyacrylate c. a water absorber and optionally d. a non-adhesive hydrophilic polyacrylate e. a softener and/or penetration accelerator.

We claim: 
     
       1. A topical therapeutic system comprising an impermeable backing layer, an active substance containing matrix and a removable protective layer, the matrix comprising: a) 5-fluorouracil   b) a self-adhesive polyacrylate   c) a water absorber based on cross-linked neutralized polyacrylic acid, and optionally     d) a non-adhesive hydrophilic polyacrylate and/or   e) a softener and/or penetration accelerator.   
     
     
       2. A topical therapeutic system according to claim 1, wherein the matrix comprises by weight: a) 0.2-5% of 5-fluorouracil,   b) at least 50% of a self-adhesive polyacrylate,   c) 1-15% of the water absorber,   d) 0-48.8% of a non-adhesive hydrophilic polyacrylate, and   e) 0-20% of a softener and/or penetration accelerator.   
     
     
       3. A topical therapeutic system according to claim 1, wherein the matrix comprises by weight: a) 0.3-1% of 5-fluorouracil,   b) 65-75% of a self-adhesive polyacrylate,   c) 1-10% of the water absorber,   d) 10-35% of a non-adhesive hydrophilic polyacrylate, and   e) 5-15% of a softener and/or penetration accelerator.   
     
     
       4. A topical therapeutic system according to claim 1, wherein the matrix comprises by weight: a) 0.6-0.9% of 5-fluorouracil,   b) 65-75% of a self-adhesive polyacrylate,   c) 4-5% of the water absorber,   d) 15-25% of a non-adhesive hydrophilic polyacrylate, and   e) 5-10% of a softener and/or penetration accelerator.   
     
     
       5. A topical therapeutic system according to claim 1, wherein (e) is 1,2-propanediol. 
     
     
       6. A topical therapeutic system according to claim 1, wherein the matrix has a circular shape and a diameter of 0.5-3 cm. 
     
     
       7. A topical therapeutic system according to claim 1, wherein the matrix has a circular shape and a diameter of 1-2 cm. 
     
     
       8. A topical therapeutic system according to claim 1, wherein the matrix has a circular shape and a diameter of 1-1.3 cm. 
     
     
       9. A topical therapeutic system according to claim 1, wherein the matrix has a rectangular shape and an area of 1 to 200 cm 2 . 
     
     
       10. A topical therapeutic system according to claim 1, wherein the matrix has a rectangular shape and an area of 1 to 50 cm 2 . 
     
     
       11. A topical therapeutic system according to claim 1, wherein the matrix has a rectangular shape and an area of 2 to 20 cm 2 . 
     
     
       12. A topical therapeutic system according to claim 1, wherein the water absorber (c) is not homogeneously diluted in the matrix.