Reconstituted HDL particles and uses thereof

Abstract

A reconstituted high density lipoprotein containing particle is disclosed. The particle is useful in removing excess lipid soluble material from a subject to which it is administered, as well as in delivery of lipid soluble pharmaceuticals to subjects or patients.

We claim: 
     
       1. Method for treating a subject for endotoxin caused toxicity comprising administering to said subject an amount of a reconstituted, cholesterol free particle which contains (i) an HDL associated apolipoprotein and (ii) a lipid in which the endotoxin causing said toxicity is soluble sufficient to alleviate toxicity caused by said endotoxin. 
     
     
       2. Method for treating a subject for endotoxin caused toxicity comprising administering to said subject an amount of a reconstituted particle containing (i) cholesterol, (ii) an HDL associated apolipoprotein, and (iii) a lipid in which endotoxin causing said toxicity is soluble, in an amount sufficient to alleviate toxicity caused by said endotoxin. 
     
     
       3. Method of claim 1, wherein said reconstituted particle consists of said high density lipoprotein associated apolipoprotein associated apolipoprotein is apolipoprotein AI. 
     
     
       4. Method of claim 1, wherein said high density lipoprotein associated apolipoprotein is apolipoprotein AII. 
     
     
       5. Method of claim 1, wherein said high density lipoprotein associated apolipoprotein is apolipoprotein AII. 
     
     
       6. Method of claim 2, wherein said high density lipoprotein associated apolipoprotein is apolipoprotein AI. 
     
     
       7. Method of claim 2, wherein said high density lipoprotein associated apolipoprotein is apolipoprotein AII.