Process for the production of antibiotic R106 by a strain of Aureobasidium pullulans

Abstract

An antibiotic R106 represented by the general formula (I): ##STR1## wherein: R is methyl or ethyl; X 1 is MePhe, β-HOMePhe or Phe; X 2 is allo-Ile, Val or Leu; X 3 is MeVal or Val; X 4 is β-HOMeVal, γHOMeVal, MeVal, Val, N,β-MeAsp, β-HOMePhe, MePhe, MeDH 2 ,3 Val or MeDH 3 ,4 Val is produced by a process which comprises culturing a strain of the genus Aureobasidium that is capable of producing the said antibiotic R106 and collecting the said antibiotic from the fermentation broth. The antibiotic R106 compounds are useful in the treatment of fungal infection.

What is claimed is: 
     
       1. A process for the production of antibiotic R106 represented by formula (I) below, comprising culturing a strain of Aureobasidium pullulans having all the identifying characteristics of Aureobasidium pullulans FERM BP-1938 or a mutant thereof capable of producing antibiotic R106 in an aqueous nutrient medium containing assimilable sources of carbon, nitrogen, and inorganic substances and recovering the antibiotic from the fermentation medium ##STR10## wherein: R is methyl or ethyl; X 1  is MePhe, β-HOMePhe or Phe;   X 2  is allo-Ile, Val or Leu;   X 3  is MeVal or Val;   X 4  is β-HOMeVal, γ-HOMeVal, MeVal, Val, N,β-MeAsp, β-HOMephe, MePhe, MeDH 2 ,3 Val or MeDH 3 ,4 Val.