Quinoline derivatives

Abstract

Quinoline derivatives of the formula, ##STR1## wherein > A represents a group >N--(CH 2 ) n --, >C═, >C═CH(CH 2 ) n --, or >CH(CH 2 ) n --, wherein n is an integer of 0-7; Y represents a group >C═O or >CHOH, R 1 is a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group, or an alkylthio group, R 2 is a hydrogen atom, a halogen atom, an alkyl group, a hydroxy group, an alkoxy group, a phenyl group which may have a substituent, a phenoxy group, an alkanoyloxy group, or an amino group which may have a substituent, R 3 is a hydrogen atom, a halogen atom, an alkyl group, or an alkoxy group, and m is an integer of 1-3. The compounds and their salts exhibit a superior antiacetylcholinesterase activity with no side effects and are effective for the prevention or cure of senile dementia or memory disturbance.

What is claimed is: 
     
       1. A quinoline compound represented by the following formula (I): ##STR12## wherein >A- represents a group >N-(CH 2 ) n  -, wherein n is an integer of 0-7; Y represents a group >C=O or >CHOH, R 1  is a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group, or an alkylthio group, R 2  is a hydrogen atom, a halogen atom, an alkyl group, a hydroxy group, an alkoxy group, a phenyl group which may have a substrtuent, a phenoxy group, an alkanoyloxy group, or an amino group which may have a substituent, R 3  is a hydrogen atom, a halogen atom, an alkyl group, or an alkoxy group, and m is an integer of 1-2; or a salt thereof. 
     
     
       2. A composition for inhibiting acetylcholinesterase comprising the quinoline compound or its salt as defined in claim 1 and a pharmaceutically acceptable carrier. 
     
     
       3. A method for treating dementia comprising administering an effective dose of the quinoline compound or its salt as defined in claim 1 to a subject suffering from or under the risks of suffering from dementia.