Composition for prevention and (or) treatment of Aids

Abstract

A method for treatment of Lymphadenopathy, AIDS and AIDS related complex which comprises administering FK-565 or its pharmaceutically acceptable salt and AZT.

We claim: 
     
       1. A method for prevention and (or) treatment of AIDS, AIDS related complex and Lymphoadenopathy in a human being which comprises administering to the human being synergistically effective amounts of FK-565 or its pharmaceutically acceptable salt 1-4 times per week at a dose level of about 10-1000 μg per kilogram body weight of the patients, and administering orally to the patients synergistically effective amounts of AZT 3-8 times per day at a dose level less than 3.3 mg per kilogram body weight of the patients. 
     
     
       2. A method for treatment of AIDS, AIDS related complex and Lymphoadenopathy in a human being in need thereof, which comprises administering intravenously to the human being synergistically effective amounts of FK-565 or its pharmaceutically acceptable salt 1-4 times per week at a dose level of about 10-1000 μg per kilogram body weight of human being, and administering synergistically effective amounts of AZT orally to the human being 3-8 times per day at a dose level less than 3.3 mg per kilogram body weight of human being. 
     
     
       3. A method for prolongation of the survival of patients with AIDS, AIDS related complex and (or) Lymphoadenopathy, which comprises administering to the patients synergistically effective amounts of FK-565 or its pharmaceutically acceptable salt 1-4 times per week at a dose level of about 10-1000 μg per kilogram body weight of the patients, and administering orally to the patients synergistically effective amounts of AZT 3-8 times per day at a dose level less than 3.3 mg per kilogram body weight of the patients. 
     
     
       4. A method for prolongation of the survival of patients infected with HIV or having symptoms of AIDS, AIDS related complex or Lymphoadenopathy, which comprises administering intravenously to the patients synergistically effective amounts of FK-565 or its pharmaceutically acceptable salt 1-4 times per week at a dose level of about 10-1000 μg per kilogram body weight of the patients, and administering orally to the patients synergistically effective amounts of AZT 3-8 times per day at a dose level less than 3.3 mg per kilogram body weight of the patients. 
     
     
       5. A method for decreasing the effective amount of AZT during treatment of patients infected with HIV or having symptoms of AIDS, AIDS-related complex and with Lymphoadenopathy, which comprises reducing the AZT dose by using synergistically effective amounts of AZT at a dose level less than 3.3 mg per kilogram body weight of human being in combination with synergistically effective amounts of FK-565 or its pharmaceutically acceptable salt 1-4 times per week at a dose level of about 10-1000 μg per kilogram body weight of human being.