Methods for promoting wound healing with deoxyribonucleosides

Abstract

Methods are provided for promoting wound healing in animals by administering compositions containing two or more of the following 2'-deoxyribonucleosides: 2'-deoxyadenosine, 2'-deoxyguanosine, 2'-deoxy-cytidine, or thymidine. 3'- and 5'-phosphate derivatives of these 2'-deoxynucleosides are also effective in promoting wound healing.

What is claimed is: 
     
       1. A method for promoting wound healing comprising administering to an animal possessing a wound a wound healing effective amount of a composition of matter comprising, (a) from 10 to 90 percent by mol 2'-deoxycytidine, and   (b) from 90 to 10 percent by mol 2'-deoxyguanosine,   or the pharmaceutically acceptable salts thereof.   
     
     
       2. A method as in claim 1 wherein said composition of matter further comprises (c) 2'-deoxyadenosine or a pharmaceutically acceptable salt thereof. 
     
     
       3. A method as in claim 1 wherein said composition of matter further comprises (c) 2'-deoxythymidine or a pharmaceutically acceptable salt thereof. 
     
     
       4. A method as in claim 1 wherein said composition of matter further comprises (d) 2'-deoxythymidine or a pharmaceutically acceptable salt thereof. 
     
     
       5. A method for promoting wound healing comprising administering to an animal possessing a wound a wound healing effective amount of a composition of matter comprising, (a) from 10 to 90 percent by mol of a 3'- or 5'-phosphate, or a 3',5'-diphosphate ester of 2'-deoxycytidine, and   (b) from 90 to 10 percent by mol of a 3'- or 5'-phosphate, or a 3'- or 5'-diphosphate ester of 2'-deoxyguanosine,   or the pharmaceutically acceptable salts thereof.   
     
     
       6. A method as in claim 5 wherein said composition of matter further comprises (c) a 3'- or 5'-phosphate, or a 3',5'-diphosphate ester of 2'-deoxyadenosine, or a pharmaceutically acceptable salt thereof. 
     
     
       7. A method as in claim 5 wherein said composition of matter further comprises (c) a 3'- or 5'-phosphate, or a 3',5'-diphosphate ester of 2'-deoxythymidine, or a pharmaceutically acceptable salt thereof. 
     
     
       8. A method as in claim 6 wherein said composition of matter further comprises (d) a 3'- or 5'-phosphate, or a 3',5'-diphosphate ester of 2'-deoxythymidine, or a pharmaceutically acceptable salt thereof. 
     
     
       9. A method as in claim 1 or 5 further comprising a pharmaceutically acceptable carrier. 
     
     
       10. A method as in claim 1 or 5 wherein said wound is a mucosal wound. 
     
     
       11. A method as in claim 1 or 5 wherein said wound is a dermal wound. 
     
     
       12. A method as in claim 1 or 5 wherein said wound is a surgical incision. 
     
     
       13. A method as in claim 1 or 5 wherein said wound is a burn. 
     
     
       14. A method as in claim 1 or 5 wherein said wound is an ulcer. 
     
     
       15. A method as in claim 14 wherein said ulcer is a dermal ulcer. 
     
     
       16. A method as in claim 14 wherein said ulcer is a mucosal ulcer. 
     
     
       17. A method for promoting gastric or duodenal ulcer healing comprising administering to an animal possessing a gastric or duodenal ulcer a gastric or duodenal ulcer-healing effective amount of a composition of matter comprising, (a) from 10 to 90 percent by mol 2'-deoxycytidine, and   (b) from 90 to 10 percent by mol 2'-deoxyguanosine,   or the pharmaceutically acceptable salts thereof.   
     
     
       18. A method as in claim 17 wherein said composition of matter further comprises (c) 2'-deoxyadenosine or a pharmaceutically acceptable salt thereof. 
     
     
       19. A method as in claim 17 wherein said composition of matter further comprises (c) 2'-deoxythymidine or a pharmaceutically acceptable salt thereof. 
     
     
       20. A method as in claim 18 wherein said composition of matter further comprises (d) 2'-deoxythymidine or a pharmaceutically acceptable salt thereof. 
     
     
       21. A method for promoting gastric or duodenal ulcer healing comprising administering to an animal possessing a gastric or duodenal ulcer a gastric or duodenal ulcer-healing effective amount of a composition of matter comprising, (a) from 10 to 90 percent by mol of a 3'- or 5'-phosphate, or a 3',5'-diphosphate ester of 2'-deoxycytidine, and   (b) from 90 to 10 percent by mol of a 3', a 5' phosphate, or a 3',5'-diphosphate ester of 2'-deoxyguanosine,   or the pharmaceutically acceptable salts thereof.   
     
     
       22. A method as in claim 21 wherein said composition of matter further comprises (c) a 3'- or 5'-phosphate, or a 3',5'-diphosphate ester of 2'-deoxyadenosine, or a pharmaceutically acceptable salt thereof. 
     
     
       23. A method as in claim 21 wherein said composition of matter further comprises (c) a 3'- or 5'-phosphate, or a 3',5'-diphosphate ester of 2'-deoxythymidine, or a pharmaceutically acceptable salt thereof. 
     
     
       24. A method as in claim 22 wherein said composition of matter further comprises (d) a, 3',5' phosphate or a 3', 5'-diphosphate ester of 2'-deoxythymidine, or a pharmaceutically acceptable salt thereof. 
     
     
       25. A method for promoting wound healing comprising administering to an animal possessing a wound a wound healing effective amount of a composition of matter comprising, (a) from 10 to 90 percent by mol 2'-deoxycytidine, and   (b) from 90 to 10 percent by mol 2'-deoxyguanosine,   or the pharmaceutically acceptable salts thereof, in the form of a liposome.   
     
     
       26. A method as in claim 25 wherein said composition of matter further comprises (c) 2'-deoxyadenosine or a pharmaceutically acceptable salt thereof. 
     
     
       27. A method as in claim 25 wherein said composition of matter further comprises (c) 2'-deoxythymidine or a pharmaceutically acceptable salt thereof. 
     
     
       28. A method as in claim 26 wherein said composition of matter further comprises (d) 2'-deoxythymidine or a pharmaceutically acceptable salt thereof. 
     
     
       29. A method for promoting wound healing comprising administering to an animal possessing a wound a wound healing effective amount of a composition of matter comprising, (a) from 10 to 90 percent by mol of a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxycytidine, and   (b) from 90 to 10 percent by mol of a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxyguanosine,   or the pharmaceutically acceptable salts thereof, in the form of a liposome.   
     
     
       30. A method as in claim 29 wherein said composition of matter further comprises (c) a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxyadenosine, or a pharmaceutically acceptable salt thereof. 
     
     
       31. A method as in claim 29 wherein said composition of matter further comprises (c) a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxythymidine, or a pharmaceutically acceptable salt thereof. 
     
     
       32. A method as in claim 30 wherein said composition of matter further comprises (d) a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxythymidine, or a pharmaceutically acceptable salt thereof. 
     
     
       33. A method for promoting wound healing in an animal with corticosteroid-induced impaired wound healing comprising administering to the wound a wound healing effective amount of a composition of matter comprising, (a) from 10 to 90 percent by mol 2'-deoxycytidine, and   (b) from 90 to 10 percent by mol 2'-deoxyguanosine, or the pharmaceutically acceptable salts thereof.   
     
     
       34. A method as in claim 33 wherein said composition of matter further comprises (c) 2'-deoxyadenosine or a pharmaceutically acceptable salt thereof. 
     
     
       35. A method as in claim 33 wherein said composition of matter further comprises (c) 2'-deoxythymidine or a pharmaceutically acceptable salt thereof. 
     
     
       36. A method as in claim 34 wherein said composition of matter further comprises (d) 2'-deoxythymidine or a pharmaceutically acceptable salt thereof. 
     
     
       37. A method for promoting wound healing in an animal with corticosteroid-induced impaired wound healing comprising administering to the wound a wound healing effective amount of a composition of matter comprising, (a) from 10 to 90 percent by mol of a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxycytidine, and   (b) from 90 to 10 percent by mol of a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxyguanosine,   or the pharmaceutically acceptable salts thereof.   
     
     
       38. A method as in claim 37 wherein said composition of matter further comprises (c) a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxyadenosine, or a pharmaceutically acceptable salt thereof. 
     
     
       39. A method as in claim 37 wherein said composition of matter further comprises (c) a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxythymidine, or a pharmaceutically acceptable salt thereof. 
     
     
       40. A method as in claim 38 wherein said composition of matter further comprises (d) a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxythymidine, or a pharmaceutically acceptable salt thereof.