3-Isoxazoyl derivatives endowed with anticonvulsant activity, procedure for their preparation and their pharmaceutical compositions

Abstract

The object of the invention is heterocyclic compounds of general formula (I) endowed with anticonvulsant activity: <IMAGE> I in which Y is selected from -O-, -S- and <IMAGE> R4 being H or optionally substituted alkyl, acyl or benzyl, Z is selected from the groups -CO-N(R6)-,-NH-CO-CH=CH- and -N(R6)-CO, R6 being H or alkyl; R1 is C1-C4 alkyl; R2 is C1-C4 alkyl or halogen; R3 represents optionally substituted C1-C4 alkyl, alkoxy or hydroxyalkyl, or C2-C7 alkanoyl.

We claim: 
     
       1. The compound N-( 5-hydroxymethyl-3-isoxazolyl)-2,6-dimethyl-benzamide. 
     
     
       2. The compound N-(5- methyl-3-isoxazolyl)-2,6-dimethyl-benzamide. 
     
     
       3. A pharmaceutical composition useful in treating epilepsy, which contains as active ingredient a pharmaceutically effective amount of a compound selected from the group consisting of N-(5-hydroxymethyl-3-isoxazolyl)-2,6-dimethyl-benzamide and N-(5-methyl-3-isoxazolyl)-2,6-dimethyl-benzamide and a carrier or excipient. 
     
     
       4. A method for treating epilepsy in a patient, which comprises administering to said patient a therapeutically effective amount of a compound selected from the group consisting of N-(5-hydroxymethyl-3-isoxazolyl)-2,6-dimethyl-benzamide and N-(5-methyl-3-isoxazolyl)-2,6-dimethyl-benzamide.